Lambert Lab Shows HPV Works Across Cellular Borders to Drive Cervical Cancer

Expression of both HPV oncogenes E6/E7 and estrogen (E2) alter host gene expression in the cervical stroma. The Venn diagrams and pie charts in this figure show the differential expression of genes in the stroma for E6/E7, E2, and E6/E7+E2 compared to WT mice. From Spurgeon et al., PNAS. 2017 Oct 9; 114(43): E9076-E9085. Human …

Xu Lab Study Shows How Cells Can be Led Down Non-Cancer Path

Dr. Xu and her lab group. From left to right: Kristine Donahue, lead author Fabao Liu, author Yidan Wang, Justine Coburn, Carlos Coriano, senior author Wei Xu, Steve Chan, Eui-Jun Kim, and Dominic Dharam. Contributing scientists not pictured: Fengfei Ma, Yuyuan Wang, Ling Hao, Hao Zeng, Chenxi Jia, Peng Liu, Irene M. Ong, Baobin Li, Guojun …

UWCCC Hosts Seminars on Multiple Myeloma Research

Prior to 2003, there was almost no multiple myeloma (MM) research ongoing at UW–Madison. However, the Trillium Fund was established that year by several generous patients to support myeloma research at the UW Carbone Cancer Center. In 2004, Dr. Natalie Callander was recruited to the UW–Madison and the Multiple Myeloma Working Group was established. Now, the …

Remembering McArdle’s Early History

Roz Boutwell and Alex Law On June 6, 2014, Dr. Roswell “Roz” Boutwell gave a talk on McArdle’s early history. Dr. Boutwell had joined McArdle in 1945, and was one of the core faculty members who helped transform McArdle into a leading cancer research institute. His talk highlighted his role along with the role of …

Xu Named Marian A. Messerschmidt Professor in Cancer Research

Wei Xu, right, with McArdle Director Paul Lambert and Ron and Ruth Niendorf. Mr. and Mrs. Niendorf were friends and neighbors of Marian Burgenske, and helped her establish the endowment for Dr. Xu’s professorship. McArdle is excited to announce that Wei Xu has been named the new Marian A. Messerschmidt Professor in Cancer Research. Dr. Xu, who has been a faculty …

Decades-Old Research is Basis for New Cervical Cancer Clinical Trial

Research that began at the McArdle Laboratory for Cancer Research and the UW Carbone Cancer Center decades ago has led to a promising clinical trial for women in parts of the developing world, and could lead to more treatment options for cervical cancer all over the world. View the Full Article

New Book Chronicles the Historic Work of McArdle Scientists Elizabeth and James Miller on the Origins and Prevention of Cancer

The Understanding, Prevention and Control of Human Cancer; The Historic Work and Lives of Elizabeth Cavert Miller and James A Miller, by Robert G. McKinnell, University of Minnesota, is an account of how a married couple opened understanding of environmental carcinogenesis. Access This Publication

Paul Ahlquist receives Hilldale Award

Paul Ahlquist, Ph.D., Paul J. Kaesberg Professor of Molecular Virology, Oncology and Plant Pathology; Lead Scientist for Virology, Morgridge Institute for Research; Howard Hughes Medical Institute Investigator, was named recipient of the University of Wisconsin–Madison’s prestigious Hilldale Award. View the Full Article

‘Viral” Video Shows HIV RNAs Bursting from Host

Nathan Sherer, Ph.D., Assistant Professor of Molecular Virology and Oncology, and researchers Ginger Pocock and Jordan Becker in collaboration with Paul Ahlquist, Ph.D., Paul J. Kaesberg Professor of Molecular Virology, Oncology and Plant Pathology have leveraged some helpful technology to make HIV and its components fluoresce, revealing what their new study calls “striking, unexpected features” …

Wei Xu receives Romnes Fellowship

Wei Xu, Ph.D., Professor of Oncology, is among 12 professors to receive a Romnes Faculty Fellowship. View the Full Article