Department of Oncology
NF-κB/RelA Signaling Required for CD40-Induced Humoral Immunity Depends on Specific NEMO Lysine Residues in Mice. The NF-κB signaling pathway serves several key purposes in biology, often focused on immune cells. Using their deep understanding of a specific branch of this signaling pathway, Dr. Miyamoto’s team (along with two more junior McArdle faculty, Drs. Dinh and …
McArdle graduate student Carstyn Joiner has been awarded a Kirschstein-NRSA Predoctoral Fellowship (F31) from the National Cancer Institute (NCI). The F31 fellowship is designed to support specialized training for promising graduate students and build on their potential to become productive, independent research scientists. Carstyn, who joined the Cancer Biology Graduate Program in 2022, is carrying …
Spurgeon ME, Lange TE, Baty A, Li H, Lambert PF, Setchell KDR, Wells SI, Zhao X. Lipid reprogramming of stratified squamous epithelium by the high-risk HPV E6 and E6/E7 oncoproteins. Metabolomics. 2026 Jul 1;22(4):111. doi: 10.1007/s11306-026-02498-2. PMID: 42384270; PMCID: PMC13323514. Viruses cleverly manipulate their host cells to support their maintenance, replication and spread. Genes and …
Umar SA, Wang W, Jeon D, Pham LK, Ward-Shaw ET, Lee D, Hu R, Bilger A, Spurgeon ME, Lambert PF. Estrogen receptor α (Esr1) mediates estrogen’s ability to promote papillomavirus-induced cutaneous disease in male and female mice. mBio. 2026 May 29:e0078326. doi: 10.1128/mbio.00783-26. Epub ahead of print. PMID: 42212803. Tumors of reproductive tissues often use …
Deming DA, Kraus SG, Brand J, Johnson KA, Abbott D, Kratz J, Turk AA, Emmerich P, Carchman E, Lubner SJ, LoConte NK, Uboha NV, Chaudhuri S, Shah R, Field A, Field E, Pasch CA, Kim DH, Weber S, Heise C, Lawson E, Sanger C, Matkowskyj K, Asimakopoulos F, Eickhoff J, Dinh HQ, Bassetti MF. Tumor …
In the past school year students at Freedom High School raised and donated over $14,000 for cancer research at the McArdle Laboratory for Cancer Research. The Freedom community, a town of ~6300 residents located between Appleton and Green Bay, has supported the students and their efforts to raise funds for cancer research for well over …
McArdle Laboratory for Cancer Research April 2026 Publications Abrahams RR, Larsen CIS, Ha R, Majumder K. The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of wild-type adeno-associated virus type 2 (wtAAV2) to cellular sites of DNA damage. J Virol. 2026 Apr 29:e0030626. doi: 10.1128/jvi.00306-26. PMID: 42053296. Since adeno-associated viruses (AAVs) are used …
Alexandra and Bill Dove spent over 50 years carrying out research at the McArdle Laboratory for Cancer Research. In addition to their scientific accomplishments, they leave behind a legacy of outreach and connection. Now Bill and Alexandra’s granddaughter, Miranda Garcia-Dove, a junior at UW–Madison, is continuing their commitment to bringing people together from diverse backgrounds …
McArdle Laboratory for Cancer Research March 2026 Publications Fahl WE, Goesch HR, Goesch SR, Fahl BL. A Defined Patho-Mechanism for Acute Radiation Syndrome Death and a Three-Drug Regimen to Prevent It. Int J Mol Sci. 2026 Mar 14;27(6):2659. doi: 10.3390/ijms27062659. PMID: 41898522; PMCID: PMC13026317. Acute Radiation Syndrome mortality is driven by gastrointestinal barrier failure, which …
On February 9th, Verona Area High School Staff and Saturn’s 8 DJs hosted a raffle and trivia night at The Seminole Tap in Fitchburg. All proceeds benefit the UW McArdle Lab for Cancer Research toward the prevention and treatment of all types of cancer. Over the past 19 years, the Night of Hope has raised …