Department of Oncology
NF-κB/RelA Signaling Required for CD40-Induced Humoral Immunity Depends on Specific NEMO Lysine Residues in Mice. The NF-κB signaling pathway serves several key purposes in biology, often focused on immune cells. Using their deep understanding of a specific branch of this signaling pathway, Dr. Miyamoto’s team (along with two more junior McArdle faculty, Drs. Dinh and …
Spurgeon ME, Lange TE, Baty A, Li H, Lambert PF, Setchell KDR, Wells SI, Zhao X. Lipid reprogramming of stratified squamous epithelium by the high-risk HPV E6 and E6/E7 oncoproteins. Metabolomics. 2026 Jul 1;22(4):111. doi: 10.1007/s11306-026-02498-2. PMID: 42384270; PMCID: PMC13323514. Viruses cleverly manipulate their host cells to support their maintenance, replication and spread. Genes and …
Umar SA, Wang W, Jeon D, Pham LK, Ward-Shaw ET, Lee D, Hu R, Bilger A, Spurgeon ME, Lambert PF. Estrogen receptor α (Esr1) mediates estrogen’s ability to promote papillomavirus-induced cutaneous disease in male and female mice. mBio. 2026 May 29:e0078326. doi: 10.1128/mbio.00783-26. Epub ahead of print. PMID: 42212803. Tumors of reproductive tissues often use …
Deming DA, Kraus SG, Brand J, Johnson KA, Abbott D, Kratz J, Turk AA, Emmerich P, Carchman E, Lubner SJ, LoConte NK, Uboha NV, Chaudhuri S, Shah R, Field A, Field E, Pasch CA, Kim DH, Weber S, Heise C, Lawson E, Sanger C, Matkowskyj K, Asimakopoulos F, Eickhoff J, Dinh HQ, Bassetti MF. Tumor …
McArdle Laboratory for Cancer Research April 2026 Publications Abrahams RR, Larsen CIS, Ha R, Majumder K. The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of wild-type adeno-associated virus type 2 (wtAAV2) to cellular sites of DNA damage. J Virol. 2026 Apr 29:e0030626. doi: 10.1128/jvi.00306-26. PMID: 42053296. Since adeno-associated viruses (AAVs) are used …
McArdle Laboratory for Cancer Research March 2026 Publications Fahl WE, Goesch HR, Goesch SR, Fahl BL. A Defined Patho-Mechanism for Acute Radiation Syndrome Death and a Three-Drug Regimen to Prevent It. Int J Mol Sci. 2026 Mar 14;27(6):2659. doi: 10.3390/ijms27062659. PMID: 41898522; PMCID: PMC13026317. Acute Radiation Syndrome mortality is driven by gastrointestinal barrier failure, which …