Human tumor viruses are causally associated with over 15% of all human cancers and are likely to contribute to additional cancers. Recent research in our program and elsewhere clearly demonstrates that, for many virus-associated cancers, viral gene functions are required both for tumor development and also for continued survival of malignant cells. Thus, inhibiting tumor virus infection, replication and maintenance, and/or selected viral oncogenic functions can prevent or cure many of these cancers.
Cancer genetics and eEpigenetic Mechanisms pursues basic and translational research to discover novel cancer genetic and epigenetic mechanisms, to translate mechanistic insights derived principally from mouse models and primary human cancer samples to human cancer, and to leverage the mechanistic insights to advance cancer diagnosis and treatment.
Tumor biology includes research groups working on aspects of cell biology, stem cells, transcriptional regulation and protein structure relevant to cell growth regulation, differentiation and cancer.