Jobs at McArdle

Tenure Track Faculty Positions in Tumor Virology

The McArdle Laboratory for Cancer Research, in the University of Wisconsin-Madison School of Medicine and Public Health (SMPH), is searching for two full-time faculty candidates at the tenure track Assistant or Associate Professor level.  We are seeking exceptional candidates whose research is focused on understanding how viruses cause human cancer through basic studies of the mechanisms by which viruses alter their host cells to establish productive infections, persist and induce cancer.

The new hires for these positions will move into an extremely strong, supportive research environment. Our campus includes an unusually large number of virologists, including many tumor virologists, who comprise a highly interactive and collaborative community. The tumor virologists also participate in and benefit from the Human Cancer Virology Program within the University’s NCI-designated comprehensive cancer center (Carbone Cancer Center). We are looking for candidates who will interact productively with these and other faculty in this highly collegial and collaborative academic environment. One of the two successful candidates hired from this search will be selected to become a UW-Madison faculty member and also an investigator of the Morgridge Institute for Research (https://morgridge.org), providing many synergistic benefits.

Successful candidates should have a proven record of studying one or more tumor viruses, demonstrate the potential to establish a productive, extramurally funded research program, and describe how they will contribute to mentoring and teaching undergraduate, graduate and professional students, which is fundamental to our academic mission. Successful candidates will also be expected to participate in professional, university, and community service appropriate to rank.  Specific qualifications include:

  • An M.D. or Ph.D. in virology, oncology, biochemistry, molecular and cellular biology, genetics or closely related fields required.
  • A productive record of established scholarship of national and international significance in tumor virus biology. Areas of particular interest to this search include but are not limited to understanding how human tumor viruses cause cancer, links between viruses and antiviral defenses including intrinsic, innate, or adaptive immunity, and the use of in vitro and/or in vivo models for studying human tumor viruses.
  • 3 years minimum post-doctoral experience in tumor virology is preferred.

The positions are anticipated to start on July 1, 2024. These vacancies are being posted simultaneously in two announcements (Position Vacancy Job #287562 and #288634), allowing the School of Medicine and Public Health to consider candidates with either PhD or MD degrees.

Applications submitted by January 5, 2024 will be assured full consideration.  However, these positions will remain open, and applications may be considered until both positions are filled.

Candidates holding a Ph.D. should visit job #287562 https://jobs.wisc.edu/jobs/tenure-track-faculty-in-tumor-virology-madison-wisconsin-united-states.

Candidates holding an M.D. should visit job #288634 https://jobs.wisc.edu/jobs/tenure-track-faculty-in-tumor-virology-madison-wisconsin-united-states-8f75f11c-3323-4e69-902c-2aad65a40cb6.

SMPH is committed to being a diverse, equitable, inclusive, and anti-racist workplace and is an Equal Employment Opportunity, Affirmative Action employer.

Posted 10/24/23

Research Specialist – Madison, Wisconsin, United States – Zhang Lab

The research specialist will provide technical assistance in a research project studying the mechanisms underlying the normal as well as oncogenic self-renewal of stem cells using the hematopoietic compartment as a model system. Specific duties will include: maintenance of mouse colonies (e.g. set up timed-pregnancy matings, tag and tail mice, bleed, and isolate hematopoietic tissues) and performance of lP, retro-orbital, and tail vein injections; performance of simple animal surgeries; isolation and purification of hematopoietic stem cells and progenitors from mouse fetal liver and adult bone marrow; flow cytometry analysis; tissue sectioning and staining; and common techniques in molecular biology, cell biology and biochemistry.

Apply here: https://jobs.wisc.edu/jobs/research-specialist-madison-wisconsin-united-states-cc47ec70-c876-4f09-b11f-02d5db199d6a

About the Zhang Lab

The research program in the Zhang lab focuses on cell signaling, in particular Ras signaling, in hematopoiesis and leukemogenesis. They generated and characterized multiple genetically engineered mouse models for oncogenic Ras-driven blood cancers, including juvenile monocytic leukemia, chronic myelomonocytic leukemia and its transformation to acute myeloid leukemia, multiple myeloma, and early T cell precursor acute lymphoblastic leukemia. They use these models along with cell lines and patient samples to:

1. Study how genetic mutations alter hematopoietic stem and progenitor cell functions to promote blood cancers

2. Investigate disease mechanisms using multi-Omics approach

3. Develop mechanism-based novel combination targeted therapies and immunotherapies

4. Validate therapeutic strategies in preclinical models in vitro and in vivo

Posted 10/9/23

Scientist II – Madison, Wisconsin, United States – Xing Lab

The selected candidate will collaborate with the principal investigator to advance research programs centered on characterizing cellular dysfunctions caused by disease mutations or environmental factors. The research priorities include:

1. Investigating cellular impacts of phosphatase disease mutations, especially in relation to potential therapeutic interventions or environmental influences, using patient-derived iPSCs.
2. Employing CRISPR editing to study cancer mutations across a spectrum of phosphatase substrates.
3. Investigating the perturbation in broad signaling endpoints by disease mutations or environmental factors and the resulting cellular dysfunction through systems biology and high-throughput imaging approaches.
4. Extending the results above in animal models when needed.

Furthermore, the candidate will support the PI in guiding lab members, collaborate on lab management tasks, and participate in multidisciplinary research endeavors aimed at personalized medicine and proactive disease prevention.

Apply here: https://jobs.wisc.edu/jobs/scientist-ii-madison-wisconsin-united-states-823bf40a-ae96-4dbd-83b5-edaf4dc037d1

About the Xing Lab

The Xing lab is interested in elucidation of signaling pathways related to cancer using multi-disciplinary biophysics and biochemical approaches, including structural biology and proteomics, in combination with cell biology. They focus on signaling pathways that affect cancer cell metabolism and cancer cell genome integrity.

Protein phosphatase 2A (PP2A) is involved in many essential cellular functions. Deregulation of PP2A function is frequently linked to multiple types of cancer. The importance of PP2A function also resides in its crosstalk with the Tor signaling pathway, which has broad effects on cell growth and metabolism. PP2A also interacts with PML, a major component of PML-nuclear body (PML-NB) that is missing in later stage of tumors. PML is considered an important tumor suppressor and has important functions in genome integrity and as an antiviral. Structural biology in combination with biochemistry and proteomics will provide powerful tools for elucidation of the structure and function of the key components in the regulation of PP2A, Tor and PML, as well as the crosstalk among them. Results from these aspects of our research will have a direct impact on the design of therapeutics against cancer.

Posted 10/9/23

Inventory Control Coordinator

The Department of Oncology/McArdle Laboratory for Cancer Research at the School of Medicine and Public is looking to hire a part-time laboratory support to provide dishwashing and autoclaving support to the multiple laboratories within the department conducting biological research.

The job also entails the daily operations of the departmental stockroom. These duties include assisting with daily departmental shipping, receiving and delivery needs and could involve assisting with data entry and inventory control.

This position provides an important supportive function for the department to ensure the laboratories are able to continue their research in an efficient manner.

Apply here: https://jobs.wisc.edu/jobs/inventory-control-coordinator-madison-wisconsin-united-states-22ece972-911d-4b8d-8c24-a390d3803bb1

Posted 10/9/23