We are studying the novel, RNA-based pathways and virus-host interactions underlying replication, gene expression and evolution by positive-strand RNA viruses, the largest class of viruses.
The focus of our research is on understanding the molecular mechanisms governing the activity of estrogen receptor (ER),
We study aspects of metabolic physiology that govern tumor susceptibility, notably the role of skin as a modifier of systemic metabolism.
Our laboratory is interested in a family of transcriptional regulators known as PAS proteins.
Our laboratory is focused on using chemical biology to identify and validate mitotic protein kinases as breast cancer drug targets.
Our lab is focused on defining the contribution of rare genetic variation to risk of blood disorders and cancer.
Our laboratory is investigating kinase modulation of cellular signaling pathways driven by oncogenic mutant proteins
Huy Q. Dinh
Our goal is to understand how tumor immune microenvironment changes toward finding immunotherapeutic biomarkers and targets.
Our laboratory is designed to enable cells to protect their genomes against toxic molecules, whether the toxins are formed during normal oxidative life, cancer therapy, metabolism of environmental toxicants or exposure to ionizing radiation.
Our research focuses on identifying sources of intratumoral heterogeneity and determining how such heterogeneity impacts prevention and treatment in the clinic.
Our research focuses on the molecular biology of Epstein-Barr virus (EBV) nuclear proteins, their role in the virus lifecycle and the pathogenesis of EBV associated malignancies.
Our lab focuses on determining the mechanisms of human cytomegalovirus (HCMV) replication and pathogenesis, and also uses the virus as a tool to probe the pathways that lead to cell cycle progression and oncogenesis.
Our lab focused upon understanding the molecular regulation and pathogenesis of the human herpesvirus, Epstein-Barr virus (EBV).
Our lab’s research is focused on understanding the role of human papillomavirus (HPV) in cancer.
Our lab studies the mechanisms of RNA encapsidation, initiation and synthesis of minus-strand DNA, initiation and synthesis of plus-strand DNA, and genome circularization during plus-strand DNA synthesis.
We study how viruses localize to cellular sites on the host genome to establish infection by hijacking the cell’s replication and repair machinery.
Our group’s primary interest involves regulation of gene expression and mechanisms of oncogenesis by DNA tumor viruses implicated in a variety of human cancers.
Our lab has pursued a variety of research interests centered around cell signaling and asked "what happens when cells are no longer able to communicate effectively?"
Our group is interested in the cell biology underlying the assembly and spread of the human immunodeficiency virus type 1 (HIV-1), the etiological agent causing the acquired immunodeficiency syndrome (AIDS).
The primary goals of our research group are to utilize the ACI rat model of 17β-estradiol (E2)-induced mammary cancer to identify novel genetic determinants of breast cancer susceptibility.
Our research focuses on two facets of EBV pivotal to its inducing and maintaining human tumors.
Our lab focuses on discovering the molecular mechanisms underlying force production, mitotic checkpoint control, and error correction in accurate cell division.
Our lab is determining the consequences of mitotic defects on tumor initiation, progression and response to chemotherapy,
Our lab studies elucidation of signaling pathways related to cancer using multi-disciplinary biophysics and biochemical approaches, including structural biology and proteomics, in combination with cell biology.
Our lab focuses on the transcriptional regulation of estrogen receptor (ER) signaling pathways by nuclear receptor co-factors.
Our lab focuses on studying the mechanisms underlying the normal as well as oncogenic self-renewal of stem cells using the hematopoietic compartment as a model system.
Emeritus Faculty Profiles
As an Emeritus faculty member, Dr. Dove no longer accepts students or postdocs. He continues in McArdle to study the research literature and to discuss ways to detect early neoplastic stages that are likely to progress to cancer.
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