Student Profile: Sharanya Nath

Cancer Biology student Sharanya Nath

Where are you from and what’s your previous training?

I am originally from Kolkata, West Bengal, in India, but being a military brat, I have lived everywhere in India except in Kolkata. I completed my B.Sc. (Honors) in Forensic Science at Amity University, where I gained foundational knowledge in biotechnology, forensic genetics, and toxicology. Fell in love with human genetics in the process, and to deepen my understanding of genetics, I pursued a PG Certification in Forensic Biotechnology and DNA Fingerprinting, followed by a Master of Research (MRes) in Medical Genetics at Newcastle University in the UK. My research there focused on investigating whether circulating tumor DNA (ctDNA) can be used to detect clinically actionable variants in neuroblastoma, particularly high-risk metastatic disease. The purpose of the study was to take a step forward towards establishing a framework for ctDNA studies in neuroblastoma and provide a comprehensive report on how to use ctDNA in detecting clinically relevant biomarkers in patients using a single non-invasive test. I implemented a blended approach of bioinformatics work and bench work to carry out the project methodology. As a
result, I was able to gain hands on experience in working with wet lab techniques along with bioinformatic tools. This really ignited my passion for cancer research and paved the way to my
current Ph.D. in Cancer Biology at UW-Madison.

Why Madison and the Cancer Biology program?

The Cancer Biology program at UW–Madison stood out to me for its strong emphasis on translational research, interdisciplinary training, and its access to world-class faculty who are leaders in their fields. The environment here offers a unique opportunity to collaborate with exceptional researchers and clinicians, all within one of the most research-intensive medical complexes globally. The graduate coursework is rigorous yet rewarding, designed to prepare students for impactful careers in cancer research. As an international student, I was particularly drawn to the program’s deep commitment to diversity, mentorship, and holistic student development. Being part of a historic institution like McArdle, with its long-standing legacy in pioneering cancer research, felt like the ideal setting to grow both intellectually and professionally. On a more personal note, Madison’s location on an isthmus- surrounded by beautiful lakes- immediately captivated me. Having grown up in a tropical climate, I had always dreamed of experiencing a city with true winters and snowfall. That touch of magic sealed the deal for me!

What is your favorite place/activity to hang out when you need to de-stress?

When I need to unwind, you’ll almost always find me at the Memorial Union Terrace. There’s something incredibly calming about sitting by the lake, watching the sailboats drift by with an iced coffee in hand. Whether I’m catching up with friends, reading, or just enjoying the view, it’s the perfect spot to reset. On days when I want a change of scenery (and maybe some retail therapy), I head over to Hilldale Mall. It’s my go-to for everything from a quick bite to a cozy bookstore browse. The mix of shops, restaurants, and open-air spaces makes it a fun and relaxing escape from the academic grind.

What is your home lab and what is your project focusing on?

I am a grad student in the Churpek Lab, led by Dr. Jane Churpek, where our research centers on inherited cancer susceptibility disorders and DNA damage repair mechanisms. My project focuses on mesothelioma and aims to develop a predictive model for platinum sensitivity by integrating functional assays of homologous recombination deficiency (HRD) with genome-wide mutational profiling.

Any new advice for incoming students?

Be kind to yourself and make space for both the science and the serendipity! Grad school is a wild mix of discovery, occasional chaos, and personal growth, so embrace it all. Ask the “dumb” questions (they’re usually the best ones), celebrate the small wins (like getting your Western blot to actually work), and find your people, those who’ll hype you up when your cells won’t grow and celebrate when your paper finally gets accepted. Also, don’t underestimate the power of fresh air, good coffee, and dancing it out in your kitchen after a long day in the lab. You’ve got this and it’s going to be one incredible ride!

What is one fun fact about you?

I am a trained Indian classical dancer who grew up idolizing anime detectives and reading crime thrillers in my free time. Somewhere between performing intricate dance steps on stage, binge-watching ‘CSI’ and ‘Death Note’, I realized science could be just as expressive, mysterious, and powerful as any art form or anime arc. My science journey actually began in forensic science; I have analyzed crime scene samples, tested for toxins in tissues, and even helped in a homicide case during my internship in India.