UW madison
UW School of Medicine and Public Health
Carbone Cancer Center

Michael N. Gould, Ph.D.

Michael Gould
Kelly H. Clifton Professor of Oncology
Genetics Program Member - UW Carbone Cancer Center

B.S., 1969, Zoology, University of Wisconsin-Madison
M.S., 1973, Radiological Sciences, University of Wisconsin-Madison
, 1977, Radiological Sciences, University of Wisconsin-Madison
Postdoctoral research: Argonne National Laboratory

7555 Wisconsin Instiutes for Medical Research
Office - (608) 263-6615; Lab - (608) 263-6026
Research Description: 

The focus of Dr. Michael Gould's laboratory is in breast cancer research, including both basic and translational projects.  Their major project is in breast cancer genetics. Initially, animal models are being used to look for genetic elements that prevent breast cancer. The human homologs of these elements are then tested as genetic candidates in large breast cancer case-control studies. Candidates showing significant association can serve as risk markers and may also provide a better understanding of the role of modifier genes in breast cancer risk and also provide targets for anti-cancer drug development.

Selected Recent Publications: 


Kiblawi S, Chasman D, Henning A, Park E, Poon H, Gould M, Ahlquist P, Craven M. Augmenting subnetwork inference with information extracted from the scientific literature. PLoS Comput Biol. 2019 Jun 27;15(6):e1006758. doi: 10.1371/journal.pcbi.1006758. eCollection 2019 Jun. PubMed PMID: 31246951; PubMed Central PMCID: PMC6619809.

Terry MB, Michels KB, Brody JG, Byrne C, Chen S, Jerry DJ, Malecki KMC, Martin MB, Miller RL, Neuhausen SL, Silk K, Trentham-Dietz A; Breast Cancer and the Environment Research Program (BCERP). Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research. Breast Cancer Res. 2019 Aug 20;21(1):96. doi: 10.1186/s13058-019-1168-2. Review. PubMed PMID: 31429809; PubMed Central PMCID: PMC6701090.


Homer-Bouthiette C, Zhao Y, Shunkwiler LB, Van Peel B, Garrett-Mayer E, Baird RC, Rissman AI, Guest ST, Ethier SP, John MC, Powers PA, Haag JD, Gould MN, Smits BMG. Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models. BMC Cancer. 2018 Dec 10;18(1):1233. doi: 10.1186/s12885-018-5109-8. PubMed PMID: 30526553; PubMed Central PMCID: PMC628887

Zumwalde NA, Haag JD, Gould MN, Gumperz JE. Mucosal associated invariant T cells from human breast ducts mediate a Th17-skewed response to bacterially exposed breast carcinoma cells. Breast Cancer Res. 2018 Sep 12;20(1):111. doi: 10.1186/s13058-018-1036-5. PubMed PMID: 30208917; PubMed Central PMCID: PMC6134631.


Henning AN, Haag JD, Smits BM, Gould MN. The Non-coding Mammary Carcinoma Susceptibility Locus, Mcs5c, Regulates Pappa Expression via Age-Specific Chromatin Folding and Allele-Dependent DNA Methylation. PLoS Genet. 2016 Aug 18;12(8):e1006261. doi: 10.1371/journal.pgen.1006261. eCollection 2016 Aug. PubMed PMID: 27537370; PubMed Central PMCID: PMC4990333.

Zumwalde NA, Haag JD, Sharma D, Mirrielees JA, Wilke LG, Gould MN, Gumperz JE. Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate. Cancer Prev Res (Phila). 2016 Apr;9(4):305-16. doi: 10.1158/1940-6207.CAPR-15-0370-T. Epub 2016 Jan 25. PubMed PMID: 26811335; PubMed Central PMCID: PMC4818696.


Bansal, M., Yang, J., Karan, C., Menden, M. P., Costello, J. C., Tang, H., Xiao, G., Li, Y., Allen, J., Zhong, R., Chen, B., Kim, M., Wang, T., Heiser, L. M., Realubit, R., Mattioli, M., Alvarez, M. J., Shen, Y., NCI-DREAM Community (including Gould, M. N.), Gallahan, D., Singer, D., Saez-Rodriguez, J., Xie, Y., Stolovitzky, G., and Califano, A.  A Community Computational Challenge to Predict the Activity of Pairs of Compounds.  Nat. Biotechnol., 32(12): 1213-1222, 2014.


Leng, N., Dawson, J. A., Thomson, J. A., Ruotti, V., Rissman, A. I., Smits, B. M. G., Haag, J. D., Gould, M. N., Stewart, R. M., and Kendziorski, C.  EBSeq:  An Empirical Bayes Hierarchical Model for Inference in RNA-Seq Experiments.  Bioinformatics, 29(8): 1035-1043, 2013.

Smits, B. M. G., Haag, J. D., Rissman, A. I., Sharma, D., Tran, A., Schoenborn, A. A., Baird, R. C., Peiffer, D. S., Leinweber, D. Q., Muelbl, M. J., Meilahn, A. L., Eichelberg, M. R., Leng, N., Kendziorski, C., John, M. C., Powers, P. A., Alexander, C. M., and Gould M. N.  The Gene Desert Mammary Carcinoma Susceptibility Locus Mcs1a Regulates Nr2f1 Modifying Mammary Epithelial Cell Differentiation and Proliferation.  PLoS Genet., 9(6):e1003549, 2013.


Drinkwater, N. R., and Gould, M. N.  The Long Path from QTL to Gene. PLoS Genet., 8(9):e1002975, 2012. 

Pirone, J. R., D’Arcy, M., Stewart, D. A., Hines, W. C., Johnson, M., Gould, M. N., Yaswen, P., Jerry, D. J., Schneider, S. S., and Troester, M. A.  Age-Associated Gene Expression in Normal Breast Tissue Mirrors Qualitative Age-at-Incidence Patterns for Breast Cancer.  Cancer Epidemiol. Biomarkers Prev., 21: 1735-1744, 2012.

Sharma, D., Eichelberg, M. R., Haag, J. D., Meilahn, A. L., Muelbl, M. J., Schell, K., Smits, B. M. G., and Gould, M. N.  Effective Flow Cytometric Phenotyping of Cells Using Minimal Amounts of Antibody.  BioTechniques, 53:  57-60, 2012.

Smits, B. M. G., Traun, B. D., Devries, T. L., Tran, A., Samuelson, D., Haag, J. D., and Gould, M.  An Insulator Loop Resides between the Synthetically Interacting Elements of the Human/Rat Conserved Breast Cancer Susceptibility Locus MCS5A/Mcs5a.  Nucleic Acids Res., 40: 132-147, 2012.

Perform a PubMed search for additional Gould publications

National Committees: 

Member, National Institute of Environmental Health Sciences Interagency Breast Cancer & Environmental Research Coordinating Committee, 2012-present

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