Overview of the Program
This program aims to draw together the expertise of a select group of outstanding basic cancer researcher mentors at the University of Wisconsin, with local opportunities for exposure to translational medicine, to create and formalize a program for postdoctoral training in basic cancer research. The McArdle Laboratory for Cancer Research has a long and remarkable history for innovation and discovery in cancer biology, and is an appropriate academic and administrative home for a training program. The UW Carbone Cancer Center (UWCCC) was one of the first NCI-designated Comprehensive Cancer Centers and has received continuous CCSG support for the past 40 years. Together, they constitute an unparalleled training environment, with a reputation for commitment to the education of young scientists. The trainer group (26 scientists from 13 departments) is outstanding; these faculty members have trained 65 academic professors, 50 professional scientists, 39 pharmaceutical industry scientists, a journal editor and 19 clinical scientists. They have excellent funding track records (this group is supported by $14m total, and $8m dedicated cancer research funding this year). The research focus of this group is diverse, though they share a cancer emphasis. Model systems include breast, prostate, skin, head and neck, colorectal, liver and hematopoietic tumors, and their topics include genetic susceptibility, signaling pathways, the role of metabolism, tumor microenvironment, epigenetic effects, collaborating genetic factors, immune regulation, DNA damage, and the development of microfluidic technologies that enable breakthroughs of culture technique and circulating cell capture. The program is led by Dr. Alexander (a breast cancer researcher, a former Era of Hope Scholar in the DOD Breast Cancer Research Program), with the assistance of Dr. Shigeki Miyamoto. Oversight is shared between members of a Program Committee, drawn together to represent viewpoints from basic, clinical and translational faculty members. The goal of this new Training Program is three-fold, 1) to provide more rigorous support of postdoctoral candidates during key phases of their career development, 2) to promote recruiting activities that focus on minority and underserved communities, and 3) to use the mentoring committee and other shared training responsibilities to catalyze discussion and scientific interaction between the research and clinical faculties. The scientific benefits of participation in the training program extends not only to the trainees funded by the training grant, but also to the other postdoctoral and predoctoral trainees within the participating laboratories, generating added value for this training program plan. In summary, this program will be unique on this campus for providing programmatic support for outstanding young scientists training in cancer biology, and for facilitating the translational goals of the Federal Cancer Research program, by engaging these trainees with the clinical faculty.
Nihal Ahmad, Ph.D., Associate Professor (Dermatology); Mechanisms of cancer development and identification of molecular targets for intervention; chemoprevention of cancer by naturally occurring non-toxic agents including plant-based agents, vitamins, hormones, etc.
John Denu, Ph.D., Professor (Biomolecular Chemistry); Mechanisms and biological function of reversible protein modifications involved in modulating signal transduction, chromatin dynamics and metabolism.
Patricia J. Keely, Ph.D., Professor (Cell & Regenerative Biology; Biomedical Engineering); Understanding how breast cell interactions with the extracellular matrix through integrins and small GTPases affect normal and carcinogenic cell phenotype.
Linda A. Schuler, Ph.D., V.M.D., Professor, (Comparative Biosciences); The role of prolactin in mammary cancer; prolactin receptors, signaling, and processing; prolactin actions on fetal and maternal tissues during pregnancy.
Nathan M. Sherer, Ph.D., Assistant Professor (Molecular Virology/Oncology); HIV-1 assembly and spread; host-pathogen interactions; retroviral gene regulation; virus trafficking; cell-cell communication; live cell imaging.
||Melanie Ivancic, Ph.D.||Kennedy Lab|
Brian Johnson, Ph.D.
||Ginger Pocock, Ph.D.||Ahlquist Lab|
||Michael Rowse, Ph.D.||Xing Lab|
||Halena VanDeusen, Ph.D.||Merrins Lab|
||Christopher Zahm, Ph.D.||McNeel Lab|
6435 Wisconsin Institutes for Medical Research
1111 Highland Avenue
Madison, WI 53705