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UW School of Medicine and Public Health
Carbone Cancer Center

2019 McArdle Publications

Ayuso JM, Vitek R, Swick AD, Skala MC, Wisinski KB, Kimple RJ, Lambert PF, Beebe DJ. Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells. Sci Rep. 2019 Aug 28;9(1):12480. doi: 10.1038/s41598-019-48764-3. PubMed PMID: 31462653; PubMed Central PMCID: PMC6713778.

Bath NM, Fahl WE, Redfield RR 3rd. Significant Reduction of Murine Renal Ischemia-Reperfusion Cell Death Using the Immediate-Acting PrC-210 Reactive Oxygen Species Scavenger. Transplant Direct. 2019 Jun 27;5(7):e469. doi: 10.1097/TXD.0000000000000909. eCollection 2019 Jul. PubMed PMID: 31334343; PubMed Central PMCID: PMC6616140.

Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA. Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PubMed PMID: 31487687.

Cedernaes J, Huang W, Ramsey KM, Waldeck N, Cheng L, Marcheva B, Omura C, Kobayashi Y, Peek CB, Levine DC, Dhir R, Awatramani R, Bradfield CA, Wang XA, Takahashi JS, Mokadem M, Ahima RS, Bass J. Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron. Cell Metab. 2019 May 7;29(5):1078-1091.e5. doi: 10.1016/j.cmet.2019.01.023. Epub 2019 Feb 28. PubMed PMID: 30827863; PubMed Central PMCID: PMC6506361.

Chakravorty A, Sugden B, Johannsen EC. An epigenetic journey: Epstein-Barr virus transcribes chromatinized and subsequently unchromatinized templates during its lytic cycle. J Virol. 2019 Apr 3;93(8). pii: JVI.02247-18. doi: 10.1128/JVI.02247-18. Print 2019 Apr 15.  Review.  PubMed PMID: 30700606; PubMed Central PMCID: PMC6450099.

Chen M, Choi S, Jung O, Wen T, Baum C, Thapa N, Lambert PF, Rapraeger AC, Anderson RA. The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif. Sci Rep. 2019 Jun 24;9(1):9126. doi: 10.1038/s41598-019-45671-5. PubMed PMID: 31235839; PubMed Central PMCID: PMC6591252.

Chevrette MG, Carlson CM, Ortega HE, Thomas C, Ananiev GE, Barns KJ, Book AJ, Cagnazzo J, Carlos C, Flanigan W, Grubbs KJ, Horn HA, Hoffmann FM, Klassen JL, Knack JJ, Lewin GR, McDonald BR, Muller L, Melo WGP, Pinto-Tomás AA, Schmitz A, Wendt-Pienkowski E, Wildman S, Zhao M, Zhang F, Bugni TS, Andes DR, Pupo MT, Currie CR. The antimicrobial potential of Streptomyces from insect microbiomes. Nat Commun. 2019 Jan 31;10(1):516. doi: 10.1038/s41467-019-08438-0. PubMed PMID: 30705269; PubMed Central PMCID: PMC6355912.

Chitrala KN, Yang X, Busbee B, Singh NP, Bonati L, Xing Y, Nagarkatti P, Nagarkatti M. Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Sci Rep. 2019 May 2;9(1):6810. doi: 10.1038/s41598-019-43232-4. PubMed PMID: 31048752; PubMed Central PMCID: PMC6497656.

Denomy C, Germain S, Haave B, Vizeacoumar FS, Freywald A, Weaver BA, Vizeacoumar FJ. Banding Together: A Systematic Comparison of The Cancer Genome Atlas and the Mitelman Database. Cancer Res. 2019 Aug 15. pii: canres.0585.2019. doi: 10.1158/0008-5472.CAN-19-0585. [Epub ahead of print] PubMed PMID: 31416843.

De Palma RM, Parnham SR, Li Y, Oaks JJ, Peterson YK, Szulc ZM, Roth BM, Xing Y, Ogretmen B. The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction. FASEB J. 2019 Jun;33(6):7647-7666. doi: 10.1096/fj.201802264R. Epub 2019 Mar 27. PubMed PMID: 30917007; PubMed Central PMCID: PMC6529350.

DeStefanis RA, Kratz JD, Emmerich PB, Deming DA. Targeted Therapy in Metastatic Colorectal Cancer: Current Standards and Novel Agents in Review. Curr Colorectal Cancer Rep. 2019 Apr;15(2):61-69. doi: 10.1007/s11888-019-00430-6. Epub 2019 Mar 20. PubMed PMID: 31130830; PubMed Central PMCID: PMC6528813.

Ding L, Shunkwiler LB, Harper NW, Zhao Y, Hinohara K, Huh SJ, Ekram MB, Guz J, Kern MJ, Awgulewitsch A, Shull JD, Smits BMG, Polyak K. Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment. PLoS Genet. 2019 Mar 20;15(3):e1008002. doi: 10.1371/journal.pgen.1008002. eCollection 2019 Mar. PubMed PMID: 30893315; PubMed Central PMCID: PMC6443185.

Eichelberg MR, Welch R, Guidry JT, Ali A, Ohashi M, Makielski KR, McChesney K, Van Sciver N, Lambert PF, Keles S, Kenney SC, Scott RS, Johannsen E. Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle. MBio. 2019 Aug 20;10(4). pii: e01332-19. doi: 10.1128/mBio.01332-19. PubMed PMID: 31431547; PubMed Central PMCID: PMC6703421.

Faure A, Hayes M, Sugden B. How Kaposi's sarcoma-associated herpesvirus stably transforms peripheral B cells towards lymphomagenesis. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16519-16528. doi: 10.1073/pnas.1905025116. Epub 2019 Jul 30. PubMed PMID: 31363046; PubMed Central PMCID: PMC6697783.

Fricke SL, Payne SN, Favreau PF, Kratz JD, Pasch CA, Foley TM, Yueh AE, Van De Hey DR, Depke MG, Korkos DP, Sha GC, DeStefanis RA, Clipson L, Burkard ME, Lemmon KK, Parsons BM, Kenny PA, Matkowskyj KA, Newton MA, Skala MC, Deming DA. MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers. Mol Cancer Ther. 2019 Feb;18(2):346-355. doi: 10.1158/1535-7163.MCT-18-0510. Epub 2018 Nov 13. PubMed PMID: 30425131; PubMed Central PMCID: PMC6363831.

Gelbmann CB, Kalejta RF. The Golgi sorting motifs of human cytomegalovirus UL138 are not required for latency maintenance. Virus Res. 2019 Sep;270:197646. doi: 10.1016/j.virusres.2019.197646. Epub 2019 Jun 28. PubMed PMID: 31260705; PubMed Central PMCID: PMC6697590.

Gelbmann CB, Kalejta RF. The Membrane-Spanning Peptide and Acidic Cluster Dileucine Sorting Motif of UL138 Are Required To Downregulate MRP1 Drug Transporter Function in Human Cytomegalovirus-Infected Cells. J Virol. 2019 May 15;93(11). pii: e00430-19. doi: 10.1128/JVI.00430-19. Print 2019 Jun 1. PubMed PMID: 30894470; PubMed Central PMCID: PMC6532086.

Gorbunova V, Beck JT, Hofheinz RD, Garcia-Alfonso P, Nechaeva M, Cubillo Gracian A, Mangel L, Elez Fernandez E, Deming DA, Ramanathan RK, Torres AH, Sullivan D, Luo Y, Berlin JD. A phase 2 randomised study of veliparib plus FOLFIRI±bevacizumab versus placebo plus FOLFIRI±bevacizumab in metastatic colorectal cancer. Br J Cancer. 2019 Jan;120(2):183-189. doi: 10.1038/s41416-018-0343-z. Epub 2018 Dec 11. PubMed PMID: 30531832. [Correction: Br J Cancer. 2019 Jul 26. doi: 10.1038/s41416-019-0528-0. [Epub ahead of print] PubMed PMID: 31350526.]

Hacker TA, Diarra G, Fahl BL, Back S, Kaufmann E, Fahl WE. Significant reduction of ischemia-reperfusion cell death in mouse myocardial infarcts using the immediate-acting PrC-210 ROS-scavenger. Pharmacol Res Perspect. 2019 Jul 12;7(4):e00500. doi: 10.1002/prp2.500. eCollection 2019 Aug. PubMed PMID: 31338199; PubMed Central PMCID: PMC6625532.

He C, Lv X, Huang C, Angeletti PC, Hua G, Dong J, Zhou J, Wang Z, Ma B, Chen X, Lambert PF, Rueda BR, Davis JS, Wang C. A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Rep. 2019 Mar 5;26(10):2636-2650.e5. doi: 10.1016/j.celrep.2019.02.004. PubMed PMID: 30840887.

Helzer KT, Szatkowski Ozers M, Meyer MB, Benkusky NA, Solodin N, Reese RM, Warren CL, Pike JW, Alarid ET.The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2. Mol Cell Biol. 2019 Jan 16;39(3). pii: e00417-18. doi: 10.1128/MCB.00417-18. Print 2019 Feb 1. PubMed PMID: 30455249; PubMed Central PMCID: PMC6336141.

Ivancic MM, Anson LW, Pickhardt PJ, Megna B, Pooler BD, Clipson L, Reichelderfer M, Sussman MR, Dove WF. Conserved serum protein biomarkers associated with growing early colorectal adenomas. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8471-8480. doi: 10.1073/pnas.1813212116. Epub 2019 Apr 10. PubMed PMID: 30971492; PubMed Central PMCID: PMC6486772.

Jarvis CM, Zwick DB, Grim JC, Alam MM, Prost LR, Gardiner JC, Park S, Zimdars LL, Sherer NM, Kiessling LL. Antigen structure affects cellular routing through DC-SIGN. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14862-14867. doi: 10.1073/pnas.1820165116. Epub 2019 Jul 3. PubMed PMID: 31270240; PubMed Central PMCID: PMC6660738.

Kasza I, Adler D, Nelson DW, Eric Yen CL, Dumas S, Ntambi JM, MacDougald OA, Hernando D, Porter WP, Best FA, Alexander CM. Evaporative cooling provides a major metabolic energy sink. Mol Metab. 2019 Sep;27:47-61. doi: 10.1016/j.molmet.2019.06.023. Epub 2019 Jul 1. PubMed PMID: 31302039; PubMed Central PMCID: PMC6717770.

Khan N, Jajeh F, Eberhardt EL, Miller DD, Albrecht DM, Van Doorn R, Hruby MD, Maresh ME, Clipson L, Mukhtar H, Halberg RB. Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer. Int J Cancer. 2019 Apr 24. doi: 10.1002/ijc.32367. [Epub ahead of print] PubMed PMID: 31018249.

Kiblawi S, Chasman D, Henning A, Park E, Poon H, Gould M, Ahlquist P, Craven M. Augmenting subnetwork inference with information extracted from the scientific literature. PLoS Comput Biol. 2019 Jun 27;15(6):e1006758. doi: 10.1371/journal.pcbi.1006758. eCollection 2019 Jun. PubMed PMID: 31246951; PubMed Central PMCID: PMC6619809.

Kong G, You X, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J. Downregulating Notch counteracts Kras(G12D)-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia. 2019 Mar;33(3):671-685. doi: 10.1038/s41375-018-0248-0. Epub 2018 Sep 11. PubMed PMID: 30206308; PubMed Central PMCID: PMC6405304.

Lambert PF, Sugden B. Viruses and Human Cancer. In: JE Niederhuber, JO Armitage, JH Doroshow, MB Kastan, JE Tepper (Eds.), Abeloff’s Clinical Oncology, Sixth Edition, pp. 165-179. Philadelphia: Elsevier Press, 2019.

Lee JH, Kalejta RF. Human Cytomegalovirus Enters the Primary CD34(+) Hematopoietic Progenitor Cells Where It Establishes Latency by Macropinocytosis. J Virol. 2019 Jul 17;93(15). pii: e00452-19. doi: 10.1128/JVI.00452-19. Print 2019 Aug 1. PubMed PMID: 31118259; PubMed Central PMCID: PMC6639267.

Lee JH, Pasquarella JR, Kalejta RF. Cell Line Models for Human Cytomegalovirus Latency Faithfully Mimic Viral Entry by Macropinocytosis and Endocytosis. J Virol. 2019 Aug 7. pii: JVI.01021-19. doi: 10.1128/JVI.01021-19. [Epub ahead of print] PubMed PMID: 31391271.

Liu S, Alnammi M, Ericksen SS, Voter AF, Ananiev GE, Keck JL, Hoffmann FM, Wildman SA, Gitter A. Practical Model Selection for Prospective Virtual Screening. J Chem Inf Model. 2019 Jan 28;59(1):282-293. doi: 10.1021/acs.jcim.8b00363. Epub 2018 Dec 18. PubMed PMID: 30500183; PubMed Central PMCID: PMC6351977.

Lu W, Chen S, Yu J, Behrens R, Wiggins J, Sherer N, Liu SL, Xiong Y, Xiang SH, Wu L. The Polar Region of the HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing the gp120-gp41 Association. J Virol. 2019 Mar 21;93(7). pii: e02128-18. doi: 10.1128/JVI.02128-18. Print 2019 Apr 1. PubMed PMID: 30651369; PubMed Central PMCID: PMC6430531.

Lung DK, Warrick JW, Hematti P, Callander NS, Mark CJ, Miyamoto S, Alarid ET. Bone marrow stromal cells transcriptionally repress ESR1 but cannot overcome constitutive ESR1 mutant activity. Endocrinology. 2019 Jul 25. pii: en.2019-00299. doi: 10.1210/en.2019-00299. [Epub ahead of print] PubMed PMID: 31504407.

Mescher M, Tigges J, Rolfes KM, Shen AL, Yee JS, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T. The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver. Arch Toxicol. 2019 Jul;93(7):1917-1926. doi: 10.1007/s00204-019-02488-5. Epub 2019 May 20. PubMed PMID: 31111189.

Moon JH, Hong SW, Kim JE, Shin JS, Kim JS, Jung SA, Ha SH, Lee S, Kim J, Lee DH, Park YS, Kim DM, Park SS, Hong JK, Kim DY, Kim EH, Jung J, Kim MJ, Kim SM, Deming DA, Kim K, Kim TW, Jin DH. Targeting β-catenin overcomes MEK inhibition resistance in colon cancer with KRAS and PIK3CA mutations. Br J Cancer. 2019 Apr;120(9):941-951. doi: 10.1038/s41416-019-0434-5. Epub 2019 Apr 4. PubMed PMID: 30944457

Morgan MM, Arendt LM, Alarid ET, Beebe DJ, Johnson BP. Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model. FASEB J. 2019 Jul;33(7):8623-8633. doi: 10.1096/fj.201802347RRR. Epub 2019 Apr 19. PubMed PMID: 31002529; PubMed Central PMCID: PMC6593876.

O'Driscoll CA, Owens LA, Hoffmann EJ, Gallo ME, Afrazi A, Han M, Fechner JH, Schauer JJ, Bradfield CA, Mezrich JD. Ambient urban dust particulate matter reduces pathologic T cells in the CNS and severity of EAE. Environ Res. 2019 Jan;168:178-192. doi: 10.1016/j.envres.2018.09.038. Epub 2018 Oct 1. PubMed PMID: 30316103; PubMed Central PMCID: PMC6263800.

Pasch CA, Favreau PF, Yueh AE, Babiarz CP, Gillette A, Sharick JT, Karim MR, Nickel KP, DeZeeuw AK, Sprackling CM, Emmerich PB, DeStefanis RA, Pitera RT, Payne SN, Korkos DP, Clipson L, Walsh CM, Miller D, Carchman E, Burkard ME, Lemmon KK, Matkowskyj KA, Newton MA, Ong IM, Bassetti MF, Kimple RJ, Skala MC, Deming DA. Patient-derived cancer organoid cultures to predict sensitivity to chemotherapy and radiation. Clin Cancer Res. 2019 Jun 7. pii: clincanres.3590.2018. doi: 10.1158/1078-0432.CCR-18-3590. [Epub ahead of print] PubMed PMID: 31175091; PubMed Central PMCID: PMC6726566

Pickhardt PJ, Pooler BD, Matkowskyj KA, Kim DH, Grady WM, Halberg RB. Volumetric growth rates of sessile serrated adenomas/polyps observed in situ at longitudinal CT colonography. Eur Radiol. 2019 Sep;29(9):5093-5100. doi: 10.1007/s00330-019-5999-0. Epub 2019 Feb 11. PubMed PMID: 30741343; PubMed Central PMCID: PMC6684388.

Pooler BD, Lubner MG, Theis JR, Halberg RB, Liang Z, Pickhardt PJ. Volumetric Textural Analysis of Colorectal Masses at CT Colonography: Differentiating Benign versus Malignant Pathology and Comparison with Human Reader Performance. Acad Radiol. 2019 Jan;26(1):30-37. doi: 10.1016/j.acra.2018.03.002. Epub 2018 Mar 19. PubMed PMID: 29566994.

Reese RM, Harrison MM, Alarid ET. Grainyhead-like protein 2: The emerging role in hormone-dependent cancers and epigenetics. Endocrinology. 2019 May:160(5):1275-1288. doi: 10.1210/en.2019-00213. PubMed PMID: 30958537.

Shin MK, Payne S, Bilger A, Matkowskyj KA, Carchman E, Meyer DS, Bentires-Alj M, Deming DA, Lambert PF. Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes. Clin Cancer Res. 2019 Mar 15;25(6):1889-1900. doi: 10.1158/1078-0432.CCR-18-2843. Epub 2018 Dec 7. PubMed PMID: 30530704; PubMed Central PMCID: PMC6423984..

Soukup AA, Zheng Y, Mehta C, Wu J, Liu P, Cao M, Hofmann I, Zhou Y, Zhang J, Johnson KD, Choi K, Keles S, Bresnick EH. Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer. J Clin Invest. 2019 Mar 1;129(3):1180-1192. doi: 10.1172/JCI122694. Epub 2019 Feb 11. PubMed PMID: 30620726; PubMed Central PMCID: PMC6391105

Spurgeon ME, Uberoi A, McGregor SM, Wei T, Ward-Shaw E, Lambert PF. A Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive Tract. MBio. 2019 Mar 5;10(2). pii: e00180-19. doi: 10.1128/mBio.00180-19. PubMed PMID: 30837335.

Terry MB, Michels KB, Brody JG, Byrne C, Chen S, Jerry DJ, Malecki KMC, Martin MB, Miller RL, Neuhausen SL, Silk K, Trentham-Dietz A; Breast Cancer and the Environment Research Program (BCERP). Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research. Breast Cancer Res. 2019 Aug 20;21(1):96. doi: 10.1186/s13058-019-1168-2. Review. PubMed PMID: 31429809; PubMed Central PMCID: PMC6701090.

Tikhmyanova N, Paparoidamis N, Romero-Masters J, Feng X, Mohammed FS, Reddy PAN, Kenney SC, Lieberman PM, Salvino JM. Development of a novel inducer for EBV lytic therapy. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2259-2264. doi: 10.1016/j.bmcl.2019.06.034. Epub 2019 Jun 22. PubMed PMID: 31255485; PubMed Central PMCID: PMC6690763.

Wan J, Block S, Scribano CM, Thiry R, Esbona K, Audhya A, Weaver BA. Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Nat Commun. 2019 Apr 4;10(1):1540. doi: 10.1038/s41467-019-09471-9. PubMed PMID: 30948704; PubMed Central PMCID: PMC6449396.

Wang S, Arena ET, Becker JT, Bement WM, Sherer NM, Eliceiri KW, Yuan M.Spatially Adaptive Colocalization Analysis in Dual-Color Fluorescence Microscopy. IEEE Trans Image Process. 2019 Apr 4. doi: 10.1109/TIP.2019.2909194. [Epub ahead of print] PubMed PMID: 30951467.

You X, Wen Z, Chang YI, Ranheim EA, Zhou Y, Zhou L, Kong G, Zhang J. Systemic Notch downregulation promotes KrasG12D -induced myeloproliferative neoplasm. Br J Haematol. 2019 Aug;186(3):e52-e56. doi: 10.1111/bjh.15893. Epub 2019 Mar 31. PubMed PMID: 30931528.

Zhang H, Ericksen SS, Lee CP, Ananiev GE, Wlodarchak N, Yu P, Mitchell JC, Gitter A, Wright SJ, Hoffmann FM, Wildman SA, Newton MA. Predicting kinase inhibitors using bioactivity matrix derived informer sets. PLoS Comput Biol. 2019 Aug 5;15(8):e1006813. doi: 10.1371/journal.pcbi.1006813. eCollection 2019 Aug. PubMed PMID: 31381559; PubMed Central PMCID: PMC6695194.

Zhu F, Guo H, Bates PD, Zhang S, Zhang H, Nomie KJ, Li Y, Lu L, Seibold KR, Wang F, Rumball I, Cameron H, Hoang NM, Yang DT, Xu W, Zhang L, Wang M, Capitini CM, Rui L. PRMT5 is upregulated by B-cell receptor signaling and forms a positive-feedback loop with PI3K/AKT in lymphoma cells. Leukemia. 2019 May 23. doi: 10.1038/s41375-019-0489-6. [Epub ahead of print] PubMed PMID: 31123343.

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