A Study Group on Cancer Detection – A Pan-GI resource in plasma?

Tuesday, February 15, 2022, 3-5 pm, CST, via Zoom

The Mission of Our February 15th Study Group

In June 2021 the McArdle Laboratory for Cancer Research sponsored an event on New Modalities in Cancer Detection. The power of detection by individual molecular or imaging modalities is complemented by “pan-cancer” detection strategies. If comprehensive, such a strategy can encompass rare cancer types into screens that are supported by more frequent cancer types in a population [Ahlquist 2018]. Recent publications introduced in the June 2021 event reported advances toward “pan-cancer screening” — one from the Johns Hopkins Group [Lennon et al, 2020] and the other from the GRAIL consortium [Liu et al, 2020]. A recent multi-institutional publication has reported a panel of methylated DNA sequence markers in the plasma of patients diagnosed with particular GI cancer types. On February 15, McArdle is supporting a two-hour event to study this publication [Kandimalla et al. 2021]. Experienced Commentators will include Muhammed Murtaza (molecular analysis) and Norman Drinkwater (statistical analysis). The discussions in the event will be Moderated by Paul Lambert and Bill Dove, seeded by questions submitted by Registrants.

Meeting Information

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Study Group Materials

  • Materials for February 15th Study Group
    • Kandimalla,  R, Xu J, Link A, Matsuyama T, Yamamura K, Parker MI, Uetake H, Balaguer F, Borazanci E, Tsai S, Evans D, Meltzer SJ, Baba H, Brand R, Von Hoff D, Li W, and Goel A. EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers. Clin Cancer Res, 2021; 27(22):6135-6144.

Study Group Zoom Link and Meeting Information

Tuesday, February 15, 2022, 3:00-5:00 pm, CST

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Meeting ID: 927 6679 5701
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Online Study Group Registration Form. Please register by Thursday, February 10th

Question Submission Form. Please submit questions by Monday, February 14th, 12 noon, CST.


Norman Drinkwater, Professor Emeritus of Oncology

Norman's research has focused on the identification of genetic modifiers of cancer risk and other diseases in mice. His efforts have required a heavy emphasis on the development and application of statistical and computational tools.

Muhammed Murtaza, Associate Professor of Surgery

Muhammed research includes in novel computational and molecular methods and applications for minimally invasive cancer genomics and diagnostics, including the use of circulating tumor DNA (ctDNA) analysis.


Bill Dove, Professor of Emeritus of Oncology

Bill has experience with animal models for early stages of colon cancer. He actively supports the way that a Study Group can function to promote input that brings together disparate backgrounds and disciplines to address a shared issue.

Paul Lambert, Director of the McArdle Laboratory for Cancer Research

Paul's focused on understanding the role of human papillomavirus (HPV) in cancer. HPVs cause 5% of all human cancers. These include cervical cancer, other anogenital cancers and a growing proportion of head and neck cancers.