Professor of Cell Biology
University of Oklahoma Health Sciences Center
Biomedical Research Center, Room 264
975 N.E. 10th Street
Oklahoma City, OK 73104
I was a graduate student in the laboratory of Dr. Henry Pitot, and received my Ph.D. from McArdle in 1981. I spent three years as a postdoctoral fellow in Dr. Norman Drinkwater’s laboratory, until 1985, then accepted a faculty position in the Department of Cell Biology at the University of Virginia. After eleven years in Virginia I moved to the University of Oklahoma Health Sciences Center when I am a Professor of Cell Biology and former Associate Director for Basic Sciences of the OU Cancer Center. My research has focused on the gamma-glutamyl transferase family of enzymes and their role in normal physiology and in disease. GGT1 activity increases the resistance of tumors to treatment with platinum-based therapy and alkylating agents, it is essential for reperfusion injury and has been implicated in asthma. We have identified a novel class of compounds that inhibit the enzyme. We recently solved the crystal structure of human GGT, the first structure to be determined for any eukaryotic gamma-glutamyl transferase. We are now using Structure-Based Drug Design to develop our GGT inhibitors for clinical use.