UW madison
UW School of Medicine and Public Health
Carbone Cancer Center

Marie H. Hanigan, Ph.D.

Marie H. Hanigan, Ph.D.

Professor of Cell Biology
University of Oklahoma Health Sciences Center
Biomedical Research Center, Room 264
975 N.E. 10th Street
Oklahoma City, OK 73104

I was a graduate student in the laboratory of Dr. Henry Pitot, and received my Ph.D. from McArdle in 1981. I spent three years as a postdoctoral fellow in Dr. Norman Drinkwater’s laboratory, until 1985, then accepted a faculty position in the Department of Cell Biology at the University of Virginia. After eleven years in Virginia I moved to the University of Oklahoma Health Sciences Center when I am a Professor of Cell Biology and former Associate Director for Basic Sciences of the OU Cancer Center. My research has focused on the gamma-glutamyl transferase family of enzymes and their role in normal physiology and in disease. GGT1 activity increases the resistance of tumors to treatment with platinum-based therapy and alkylating agents, it is essential for reperfusion injury and has been implicated in asthma. We have identified a novel class of compounds that inhibit the enzyme. We recently solved the crystal structure of human GGT, the first structure to be determined for any eukaryotic gamma-glutamyl transferase. We are now using Structure-Based Drug Design to develop our GGT inhibitors for clinical use.

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