6507 WI Institute Medical Research
2003, BS, Clinical Lab Science, Marquette University
2007, MD, University of Wisconsin School of Medicine and Public Health
Associate Professor Medicine, Hematology-Oncology
6507 Wisconsin Institute for Medical Research
My laboratory is investigating kinase modulation of cellular signaling pathways driven by oncogenic mutant proteins. To screen combinations of targeted agents in the setting of specific genetic alterations, novel mouse models of colorectal cancer including tumors driven by a constitutively active PI3K [Cancer Research, 2012; PLoSOne, 2013; Oncogene, 2013]. In addition to my laboratory research, I have also been active in early phase clinical trials. I have developed the concepts and chaired NCI/CTEP sponsored phase I clinical trials including AZD6244 in combination with cetuximab for KRAS mutant colorectal cancer [ASCO Annual Meeting, 2012] and ABT-888 in combination with capecitabine and oxaliplatin for BRCA mutant tumors and gastrointestinal cancers.