UW madison
UW School of Medicine and Public Health
Carbone Cancer Center

David Largaespada, Ph.D.

David Largaespada, Ph.D.

American Cancer Society Research Professor
Associate Director for Basic Science
Masonic Cancer Center at the University of Minnesota
3-129 Cancer Cardiovascular Research Building
2231 6th Street SE
Minneapolis, MN 55455

I received my Ph.D. with Rex Risser and Bill Sugden in McArdle in 1992. My laboratory is working to exploit insertional mutagenesis for cancer gene discovery and functional genomics in the mouse. We have invested heavily in the use of a vertebrate-active transposon system, called Sleeping Beauty (SB). SB is being used as a tool for forward genetic screens for cancer genes involved in osteosarcoma, hepatocellular carcinoma, gastro-intestinal tract and nervous system cancers. Other projects include development of mouse models of Neurofibromatosis Type 1 (NF1) associated cancer and testing new therapies in these models.

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