2014 McArdle Publications

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Alexander, C. M., Joshi, P. A., and Khokha, R.  Fully Interlocking:  A Story of Teamwork Among Breast Epithelial Cells.  Dev. Cell, 28(2):  114-115, 2014.

Aligeti, M., Behrens, R. T., Pocock, G. M., Schindelin, J., Dietz, C., Eliceiri, K. W., Swanson, C. M., Malim, M. H., Ahlquist, P., and Sherer, N. M.  Cooperativity Among Rev-Associated Nuclear Export Signals Regulates HIV-1 Gene Expression and Is a Determinant of Virus Species Tropism.  J. Virol., 88(24): 14207-14221, 2014.

Amos-Landgraf, J. M., Heijmans, J., Wielenga, M. C. B., Dunkin, E., Krentz, K. J., Clipson, L. Ederveen, A. G., Groothuis, P. G., Mosselman, S., Muncan, V., Hommes, D. W., Shedlovsky, A., Dove, W. F., and van den Brink, G. R.  Sex Disparity in Colonic Adenomagenesis Involves Promotion by Male Hormones, Not Protection by Female Hormones.  Proc. Natl. Acad. Sci. USA, 111(46): 16514-16519, 2014.

Bansal, M., Yang, J., Karan, C., Menden, M. P., Costello, J. C., Tang, H., Xiao, G., Li, Y., Allen, J., Zhong, R., Chen, B., Kim, M., Wang, T., Heiser, L. M., Realubit, R., Mattioli, M., Alvarez, M. J., Shen, Y., NCI-DREAM Community (including Gould, M. N. and Hoffmann, F. M.), Gallahan, D., Singer, D., Saez-Rodriguez, J., Xie, Y., Stolovitzky, G., and Califano, A.  A Community Computational Challenge to Predict the Activity of Pairs of Compounds.  Nat. Biotechnol., 32(12): 1213-1222, 2014.

Berry, S. M., Chin, E. N., Jackson, S. S., Strotman, L. N., Goel, M., Thompson, N. E., Alexander, C. M., Miyamoto, S., Burgess, R. R., and Beebe, D. J.  Weak Protein-Protein Interactions Revealed by Immiscible Filtration Assisted by Surface Tension.  Anal. Biochem., 447: 133-140, 2014.

Berry, S. M., Singh, C., Lang, J. D., Strotman, L. N., Alarid, E. T., and Beebe, D. J.  Streamlining Gene Expression Analysis:  Integration of Co-Culture and mRNA Purification.  Integr. Biol., 6(2): 224-231, 2014.

Brinkman, A. M., Wu, J., Ersland, K., and Xu, W.  Estrogen Receptor a and Aryl Hydrocarbon Receptor Independent Growth Inhibitory Effects of Aminoflavone in Breast Cancer Cells.  BMC Cancer, 14:344, 2014.

Callander, N., Markovina, S., Eickhoff, J., Hutson, P., Campbell, T., Hematti, P., Go, R., Hegeman, R., Longo, W., Williams, E., Asimakopoulos, F., and Miyamoto, S.  Acetyl-L-Carnitine (ALCAR) for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Patients with Relapsed or Refractory Multiple Myeloma Treated with Bortezomib, Doxorubicin and Low-Dose Dexamethasone:  A Study from the Wisconsin Oncology Network.  Cancer Chemother. Pharmacol., 74(4): 875-882, 2014.

Chang, Y.-I., Damnernsawad, A., Allen, L. K., Yang, D., Ranheim, E. A., Young, K. H., Zhang, J., Kong, G., Wang, J., Liu, Y., Fu, H.-Y., Yang, C.-S., Guo, J., Song, H., and Zhang, J.  Evaluation of Allelic Strength of Human TET2 Mutations and Cooperation between Tet2 Knockdown and Oncogenic Nras Mutation.  Br. J. Haematol., 166(3): 461-465, 2014.

Chasman, D., Gancarz, B., Hao, L., Ferris, M., Ahlquist, P., and Craven, M.  Inferring Host Gene Subnetworks Involved in Viral Replication.  PLoS Comput. Biol., 10(5):e1003626, 2014.

Colletti, J. A. II, Leland-Wavrin, K. M., Kurz, S. G., Hickman, M. P., Seiler, N. L., Samanas, N. B., Eckert, Q. A., Dennison, K. L., Ding, L., Schaffer, B. S., and Shull, J. D.  Validation of Six Genetic Determinants of Susceptibility to Estrogen-Induced Mammary Cancer in the Rat and Assessment of Their Relevance to Breast Cancer Risk in Humans.  G3 (Bethesda), 4(8): 1385-1394, 2014.

Dove, W., and Shedlovsky, A.  François Jacob – The Rest of the Story.  Res. Microbiol.,165(5): 362-364, 2014.

Dove, W. F., Shedlovsky, A., Clipson, L., Amos-Landgraf, J. M., Halberg, R. B., Krentz, K. J., Boehm, F. J., Newton, M. A., Adams, D. J., and Keane, T. M.  A Strategy to Identify Dominant Point Mutant Modifiers of a Quantitative Trait.  G3 (Bethesda), 4(6): 1113-1121, 2014.

Fahl, W. E.  Effect of Topical Vasoconstrictor Exposure Upon Tumoricidal Radiotherapy.  Int. J. Cancer, 135(4): 981-988, 2014.

Flister, M. J., Endres, B. T., Rudemiller, N., Sarkis, A. B., Santarriaga, S., Roy, I., Lemke, A., Geurts, A. M., Moreno, C., Ran, S., Tsaih, S.-W., De Pons, J., Carlson, D. F., Tan, W., Fahrenkrug, S. C., Lazarova, Z., Lazar, J., North, P. E., LaViolette, P. S., Dwinell, M. B., Shull, J. D., and Jacob, H. J.  CXM – A New Tool for Mapping Breast Cancer Risk in the Tumor Microenvironment.  Cancer Res., 74(22): 6419-6429, 2014.

Gao, J., Xu, D., Sabat, G., Valdivia, H., Xu, W., and Shi, N.-Q.  Disrupting KATP Channels Diminishes the Estrogen-Mediated Protection in Female Mutant Mice during Ischemia-Reperfusion.  Clin. Proteomics, 11(1):19, 2014.

Goel, S. A., Guo, L.-W., Wang, B., Guo, S., Roenneburg, D., Ananiev, G. E., Hoffmann, F. M., and Kent, K. C.  High-Throughput Screening Identifies Idarubicin as a Preferential Inhibitor of Smooth Muscle versus Endothelial Cell Proliferation.  PLoS One, 9(2):e89349, 2014.

Greco, N., Hayes, M. H., and Loeb, D. D. Snow Goose Hepatitis B Virus (SGHBV) Envelope and Capsid Proteins Independently Contribute to the Ability of SGHBV to Package Capsids Containing Single-Stranded DNA in Virions. J. Virol., 88(18): 10705-10713, 2014.

Guo, F., Stanevich, V., Wlodarchak, N., Sengupta, R., Jiang, L., Satyshur, K. A., and Xing, Y.  Structural Basis of PP2A Activation by PTPA, an ATP-dependent Activation Chaperone.  Cell Res., 24(2):  190-203, 2014.

Guo, F., Wan, L., Zheng, A., Stanevich, V., Wei, Y., Satyshur, K. A., Shen, M., Lee, W., Kang, Y., and Xing, Y.  Structural Insights Into the Tumor-Promoting Function of the MTDH-SND1 Complex.  Cell Rep., 8(6):  1704-1713, 2014.

Hao, L., Lindenbach, B., Wang, X., Dye, B., Kushner, D., He, Q., Newton, M., and Ahlquist, P.  Genome-Wide Analysis of Host Factors in Nodavirus RNA Replication.  PLoS One, 9(4):e95799, 2014.

Hooper, C., Jackson, S. S., Coughlin, E. E., Coon, J. J., and Miyamoto, S.  Covalent Modification of the NF-κB Essential Modulator (NEMO) by a Chemical Compound Can Regulate Its Ubiquitin Binding Properties in Vitro.  J. Biol. Chem., 289(48): 33161-33174, 2014.

Hope, C., Ollar, S. J., Heninger, E., Hebron, E., Jensen, J. L., Kim, J., Maroulakou, I., Miyamoto, S., Leith, C., Yang, D. T., Callander, N., Hematti, P., Chesi, M., Bergsagel, P. L., and Asimakopoulos, F.  TPL2 Kinase Regulates the Inflammatory Milieu of the Myeloma Niche.  Blood, 123(21): 3305-3315, 2014.

Hsu, K.-T., Yu, X.-M., Audhya, A. W., Jaume, J. C., Lloyd, R. V., Miyamoto, S., Prolla, T. A., and Chen, H.  Novel Approaches in Anaplastic Thyroid Cancer Therapy.  Oncologist, 19: 1148-1155, 2014.

Iempridee, T., Reusch, J. A., Riching, A., Johannsen, E. C., Dovat, S., Kenney, S. C., and Mertz, J. E.  Epstein-Barr Virus Utilizes Ikaros in Regulating Its Latent-Lytic Switch in B Cells.  J. Virol., 88(9): 4811-4827, 2014.

Irving, A. A., Yoshimi, K., Hart, M. L., Parker, T., Clipson, L., Ford, M. R., Kuramoto, T., Dove, W. F., and Amos-Landgraf, J. M.  The Utility of Apc-Mutant Rats in Modeling Human Colon Cancer.  Dis. Model. Mech., 7(11): 1215-1225, 2014.

Irving, A. A., Young, L. B., Pleiman, J. K., Konrath, M. J., Marzella, B., Nonte, M., Cacciatore, J., Ford, M. R., Clipson, L., Amos-Landgraf, J. M., and Dove, W. F.  A Simple, Quantitative Method Using Alginate Gel to Determine Rat Colonic Tumor Volume In Vivo.  Comp. Med., 64(2):  128-134, 2014.

Ivancic, M. M., Irving, A. A., Jonakin, K. G., Dove, W. F., and Sussman, M. R.  The Concentrations of EGFR, LRG1, ITIH4, and F5 in Serum Correlate with the Number of Colonic Adenomas in ApcPirc/+ Rats.  Cancer Prev. Res., 7(11): 1160-1169, 2014.

Izumo, M., Pejchal, M., Schook, A. C., Lange, R. P., Walisser, J. A., Sato, T. R., Wang, X., Bradfield, C. A., and Takahashi, J. S.  Differential Effects of Light and Feeding on Circadian Organization of Peripheral Clocks in a Forebrain Bmal1 Mutant.  eLife, 3:e04617, 2014.

Jackson, R., Togtema, M., Lambert, P. F., and Zehbe, I.  Tumourigenesis Driven by the Human Papillomavirus Type 16 Asian-American E6 Variant in a Three-Dimensional Keratinocyte Model.  PLos One, 9(7): e101540, 2014.

Jiang, S., Willox, B., Zhou, H., Holthaus, A. M., Wang, A., Shi, T. T., Maruo, S., Kharchenko, P. V., Johannsen, E. C., Kieff, E., and Zhao, B.  Epstein-Barr Virus Nuclear Antigen 3C Binds to BATF/IRF4 or SPI1/IRF4 Composite Sites and Recruits Sin3A to Repress CDKN2A.  Proc. Natl. Acad. Sci. USA, 111(1): 421-426, 2014.

Johnson, B. P., Walisser, J. A., Liu, Y., Shen, A. L., McDearmon, E. L., Moran, S. M., McIntosh, B. E., Vollrath, A. L., Schook, A. C., Takahashi, J. S., and Bradfield, C. A.  Hepatocyte Circadian Clock Controls Acetaminophen Bioactivation through NADPH-Cytochrome P450 Oxidoreductase.  Proc. Natl. Acad. Sci. USA, 111(52): 18757-18762, 2014.

Kasza, I., Suh, Y., Wollny, D., Clark, R. J., Roopra, A., Colman , R. J., MacDougald, O. A., Shedd, T. A., Nelson, D. W., Yen, M.-I., Yen., C.-L. E., and Alexander, C. M.  Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress.  PLoS Genet., 10(8):e1004514, 2014.

Kennedy, G. D., Nukaya, M., Moran, S. M., Glover, E., Weinberg, S., Balbo, S., Hecht, S. S., Pitot, H. C., Drinkwater, N. R., and Bradfield, C. A.  Liver Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Is Dependent on the Aryl Hydrocarbon Receptor and TNF/IL-1 Receptors.  Toxicol. Sci., 140(1): 135-143, 2014.

Kenney, S. C., and Mertz, J. E.  Regulation of the Latent-Lytic Switch in Epstein-Barr Virus.  Semin. Cancer Biol., 26(C): 60-68, 2014.

Kim, H., Guo, F., Brahma, S., Xing, Y ., and Burkard, M. E.  Centralspindlin Assembly and 2 Phosphorylations on MgcRacGAP by Polo-like Kinase 1 Initiate Ect2 Binding in Early Cytokinesis.  Cell Cycle, 13(18):  2952-2961, 2014.

Kim, S., and Alexander, C. M.  Tumorsphere Assay Provides More Accurate Prediction of in Vivo Responses to Chemotherapeutics.  Biotechnol. Lett., 36(3): 481-488, 2014.

Kong, G., Wunderlich, M., Yang, D., Ranheim, E. A., Young, K. H., Wang, J., Chang, Y.-I., Du, J., Liu, Y., Tey, S. R., Zhang, X., Juckett, M., Mattison, R., Damnernsawad, A., Zhang, J., Mulloy, J. C., and Zhang, J.  Combined MEK and JAK Inhibition Abrogates Murine Myeloproliferative Neoplasm.  J. Clin. Invest., 124(6): 2762-2773, 2014.

Kotlo, K., Xing, Y., Lather, S., Grillon, J. M., Johnson, K., Skidgel, R. A., Solaro, R. J., and Danziger, R. S.  PR65A Phosphorylation Regulates PP2A Complex Signaling.  PLoS ONE, 9(1):e85000, 2014.

Kurz, S. G., Dennison, K. L., Samanas, N. B., Hickman, M. P., Eckert, Q. A., Walker, T. L., Cupp, A. S., and Shull, J. D.  Ept7 Influences Estrogen Action in the Pituitary Gland and Body Weight of Rats.  Mamm. Genome, 25(5-6):  244-252, 2014.

Kuzembayeva, M., Hayes, M., and Sugden, B.  Multiple Functions Are Mediated by the miRNAs of Epstein-Barr Virus.  Curr. Opin. Virol., 7C:  61-65, 2014.

Li, F., Sewald, X., Jin, J., Sherer, N. M., and Mothes, W.  Murine Leukemia Virus Gag Localizes to the Uropod of Migrating Primary Lymphocytes.  J. Virol., 88(18): 10541-10555, 2014.

Li, H., Zhong, X., Chau, K. F., Santistevan, N. J., Guo, W., Kong, G., Li, X., Kadakia, M., Masliah, J., Chi, J., Jin, P., Zhang, J., Zhao, X., and Chang, Q.  Cell Cycle-Linked MeCP2 Phosphorylation Modulates Adult Neurogenesis Involving the Notch Signaling Pathway.  Nat. Commun., 5:5601, 2014.

Liu, Y., Johnson, B. P., Shen, A. L., Walisser, J. A., Krentz, K. J., Moran, S. M., Sullivan, R., Glover, E., Parlow, A. F., Drinkwater, N. R., Schuler, L. A., and Bradfield, C. A.  Loss of BMAL1 in Ovarian Steroidogenic Cells Results in Implantation Failure in Female Mice.  Proc. Natl. Acad. Sci. USA, 111(39): 14295-14300, 2014.

Murry, J. P., Godoy, J., Mukim, A., Swann, J., Bruce, J. W., Ahlquist, P., Bosque, A., Planelles, V., Spina, C. A., and Young, J. A. T.  Sulfonation Pathway Inhibitors Block Reactivation of Latent HIV-1.  Virology, 471-473: 1-12, 2014.

Park, J. W., Nickel, K. P., Torres, A. D., Lee, D., Lambert, P. F., and Kimple, R. J.  Human Papillomavirus Type 16 E7 Oncoprotein Causes a Delay in Repair of DNA Damage.  Radiother. Oncol., 113(3): 337-344, 2014.

Park, J. W., Shin, M.-K., and Lambert, P. F.  High Incidence of Female Reproductive Tract Cancers in FA-Deficient HPV16-Transgenic Mice Correlates with E7’s Induction of DNA Damage Response, an Activity Mediated by E7’s Inactivation of Pocket Proteins.  Oncogene, 33(26): 3383-3391, 2014.

Qin, Q., Lee, S. H., Liang, R., and Kalejta, R. F.  Insertion of Myeloid-Active Elements Into the Human Cytomegalovirus Major Immediate Early Promoter Is Not Sufficient to Drive Its Activation Upon Infection of Undifferentiated Myeloid Cells.  Virology, 448:  125-132, 2014.

Rajbhandari, P., Schalper, K. A., Solodin, N. M., Ellison-Zelski, S. J., Lu, K. P., Rimm, D. L., and Alarid, E. T.  Pin1 Modulates ERα Levels in Breast Cancer through Inhibition of Phosphorylation-Dependent Ubiquitination and Degradation.  Oncogene, 33(11): 1438-1447, 2014.

Sanalkumar, R., Johnson, K. D., Gao, X., Boyer, M. E., Chang, Y.-I., Hewitt, K. J., Zhang, J., and Bresnick, E. H.  Mechanism Governing a Stem Cell-Generating cis-Regulatory Element.  Proc. Natl. Acad. Sci. USA, 111(12): E1091-E1100, 2014. 

Sengupta, S., Johnson, B. P., Swanson, S. A., Stewart, R., Bradfield, C. A., and Thomson, J. A.  Aggregate Culture of Human Embryonic Stem Cell-Derived Hepatocytes in Suspension Are an Improved in Vitro Model for Drug Metabolism and Toxicity Testing.  Toxicol. Sci., 140(1): 236-245, 2014.

Shen, Q.-T., Schuh, A. L., Zheng, Y., Quinney, K., Wang, L., Hanna, M., Mitchell, J. C., Otegui, M. S., Ahlquist, P., Cui, Q., and Audhya, A.  Structural Analysis and Modeling Reveals New Mechanisms Governing ESCRT-III Spiral Filament Assembly.  J. Cell. Biol., 206(6): 763-777, 2014.

Shin, E. M., Hay, H. S., Lee, M. H., Goh, J. N., Tan, T. Z., Sen, Y. P., Lim, S. W., Yousef, E. M., Ong, H. T., Thike, A. A., Kong, X., Wu, Z., Mendoz, E., Sun, W., Salto-Tellez, M., Lim, C. T., Lobie, P. E., Lim, Y. P., Yap, C. T., Zeng, Q., Sethi, G., Lee, M. B., Tan, P., Goh, B. C., Miller, L. D., Thiery, J. P., Zhu, T., Gaboury, L., Tan, P. H., Hui, K. M., Yip, C. W.-C., Miyamoto, S., Kumar, A. P., and Tergaonkar, V.  DEAD-Box Helicase DP103 Defines Metastatic Potential of Human Breast Cancers.  J. Clin. Invest., 124(9):  3807-3824, 2014.

Shrestha, P., and Sugden, B.  Identification of Properties of the Kaposi's Sarcoma-Associated Herpesvirus Latent Origin of Replication That Are Essential for the Efficient Establishment and Maintenance of Intact Plasmids.  J. Virol., 88(15): 8490-8503, 2014.

Son, J., Park, J. W., Lambert, P. F., and Chung, S.-H.  Requirement of Estrogen Receptor Alpha DNA-Binding Domain for HPV Oncogene-Induced Cervical Carcinogenesis in Mice.  Carcinogenesis, 35(2):  489-496, 2014.

Soref, C. M., and Fahl, W. E.  A New Topical Vasoconstrictor-based Strategy for Prevention of Oral Mucositis.  Oral Surg. Oral Med. Oral Pathol. Oral Radiol., 117(4): 454-461, 2014.

Spurgeon, M. E., Chung, S.-H., and Lambert, P. F.  Recurrence of Cervical Cancer in Mice After Selective Estrogen Receptor Modulator Therapy.  Am. J. Pathol., 184(2):  530-540, 2014.

Stanevich, V., Zheng, A., Guo, F., Jiang, L., Wlodarchak, N., and Xing, Y.  Mechanisms of the Scaffold Subunit in Facilitating Protein Phosphatase 2A Methylation.  PLoS ONE, 9(1):e86955, 2014.

Stein, A. P., Saha, S., Liu, C. Z., Hartig, G. K., Lambert, P. F., and Kimple, R. J.  Influence of Handling Conditions on the Establishment and Propagation of Head and Neck Cancer Patient Derived Xenografts.  PLoS One, 9(6): e100995, 2014.

Stein, A. P., Saha, S., Yu, M., Kimple, R. J., and Lambert, P. F.  Prevalence of Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma in the United States Across Time.  Chem. Res. Toxicol., 27(4): 462-469, 2014.

Sugden, B.  Epstein-Barr Virus:  The Path from Association to Causality for a Ubiquitous Human Pathogen.  PLoS Biol., 12(9): e1001939, 2014.

Vereide, D. T., Seto, E., Chiu, Y.-F., Hayes, M., Tagawa, T., Grundhoff, A., Hammerschmidt, W., and Sugden, B.  Epstein-Barr Virus Maintains Lymphomas Via Its miRNAs.  Oncogene, 33(10): 1258-1264, 2014.

Vieira, V. C., Leonard, B., White, E. A., Starrett, G. J., Temiz, N. A., Lorenz, L. D., Lee, D., Soares, M. A., Lambert, P. F., Howley, P. M., and Harris, R. S.  Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B.  mBio, 5(6):  e02234-14, 2014.

Wan, L., Lu, X., Yuan, S., Wei, Y., Guo, F., Shen, M., Yuan, M., Chakrabarti, R., Hua, Y., Smith, H. A., Blanco, M. A., Chekmareva, M., Wu, H., Bronson, R. T., Haffty, B. G., Xing, Y., and Kang, Y.  MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors.  Cancer Cell, 26(1): 92-105, 2014.

Wang, J. C.-Y., Nickens, D. G., Lentz, T. B., Loeb, D. D., and Zlotnick, A.  Encapsidated Hepatitis B  Virus Reverse Transcriptase Is Poised on an Ordered RNA Lattice.  Proc. Natl. Acad. Sci. USA, 111(31): 11329-11334, 2014.

Wang, L., Zhao, Z., Meyer, M. B., Saha, S., Yu, M., Guo, A., Wisinski, K. B., Huang, W., Cai, W., Pike, J. W., Yuan, M., Ahlquist, P., and Xu, W.  CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis.  Cancer Cell, 25(1):  21-36, 2014. [ERRATUM published in Cancer Cell 2016 Jul 11;30(1):179-180]

Warren, C. J., Xu, T., Guo, K., Griffin, L. M., Westrich, J. A., Lee, D., Lambert, P. F., Santiago, M. L., and Pyeon, D.  APOBEC3A Functions As a Restriction Factor of Human Papillomavirus.  J. Virol., 89(1): 688-702, 2014.

Winkler, L. L., and Kalejta, R. F.  The 19S Proteasome Activator Promotes Human Cytomegalovirus Immediate Early Gene Expression through Proteolytic and Nonproteolytic Mechanisms. J. Virol., 88(20):  11782-11790, 2014..

Yang, B., Wagner, J., Damaschke, N., Yao, T., Wuerzberger-Davis, S. M., Lee, M.-H., Svaren, J., Miyamoto, S., and Jarrard, D. F.  A Novel Pathway Links Oxidative Stress to Loss of Insulin Growth Factor-2 (IGF2) Imprinting through NF-κB Activation.  PLoS One, 9(2):e88052, 2014.