McArdle News Archive

Horizontal rule
Horizontal rule

2014

Horizontal rule
Dr. Paul F. Lambert receives funding from the Wisconsin Partnership Program for testing new therapeutic approaches to treating cervical cancer and head/neck cancers (added 11/14)

The Wisconsin Partnership Program at the University of Wisconsin School of Medicine and Public Health recently awarded four Collaborative Health Science grants totaling nearly $2 million including one to McArdle Lab focused on human papillomaviruses. Specficially, Dr. Paul F Lambert, Director of McArdle Lab, received a three-year grant of $500,000 to identify treatments that improve outcomes for patients with cervical, or head/neck cancers caused by the human papillomavirus. Current treatments for these cancers rely on decades-old approaches and are associated with high rates of recurrence and poor survival. Lambert, who is internationally renowned for his work investigating the role of human papillomaviruses in cancer, will work with Dr. Dr. Randall Kimple, an assistant professor of human oncology, and Dr. David Beebe, a professor of biomedical engineering in carrying out a multidiscipline approach to identifying factors that drive the development of these cancers, testing drugs that inhibit these factors for their effectiveness in treating the cancers, and developing rapid and facile methods for screening patients cancers for their response to drugs as a primary approach to personalized medicine.  Funding for this project comes from the Partnership Program’s competitive Collaborative Health Sciences Program that supports novel ideas and interdisciplinary approaches to research and education benefiting the health of Wisconsin residents.

Horizontal rule

Norman Drinkwater joins the Office of the Vice Chancellor for Research and Graduate Education (added 09/14)

As a new administrative structure begins to take shape at the Office of the Vice Chancellor for Research and Graduate Education, Professor Norman Drinkwater will serve as the Interim Associate Vice Chancellor for the Biological Sciences.

View the Full Article

Horizontal rule

Paul Lambert named next Chair of Oncology (added 09/14)

Professor Paul Lambert has been chosen at the next Chair of the Department of Oncology and Director, McArdle Laboratory for Cancer Research. Lambert is a longtime professor at the University of Wisconsin-Madison.

View the Full Article

Horizontal rule

Randy Jirtle wins major award for work in epigenetics (added 09/14)

Randy Jirtle has received the Linus Pauling Functional Medicine Award for his work in epigenetics and genomic imprinting.

View the Full Article

Horizontal rule

Waclaw Szybalski - Legend in genetics at forefront of book about heroism during 20th century's darkest hours (added 09/14)

McArdle Emeritus Professor Waclaw Szybalski, age 92, has been featured for his contributions to a new book, the "Fantastic Laboratory of Dr. Weigl", documenting Dr. Rudolf Weigl's efforts to shelter elements of the Polish resistance during occupations by Germany and the Soviet Union during World War II. Professor Szybalski helped to supervise the "louse feeders" - a group of volunteers that included several prominent scientists and intellectuals seeking refuge from the occupation. The "louse feeders" donated their bodies to science, strapping cages filled with lice to their legs in order to grow the typhus bacteria needed for Weigl's production of the typhus vaccine. Professor Szybalski also cooked TNT for the resistance, and smuggled typhus vaccine to Jews in the Warsaw Ghetto.
Read more about Waclaw's amazing experiences

Horizontal rule
Bill Fahl's study offers hope against hair loss during chemotherapy (added 08/14)

A study by Bill Fahl, Professor of Oncology at the McArdle Laboratory for Cancer Research, offers hope in preventing hair loss during chemotherapy.

"UW Professor may have found cure to hair loss from chemotherapy" See Dannika Lewis' report here (News 3 at Ten)

Preclinical Study Offers Hope Against Hair Loss During Chemotherapy (UWSMPH News article)

UW Researcher's Study May Prevent Hair Loss During Chemo (Public News Service - WI article)

Horizontal rule
Internal Structure of Hepatitis B Revealed for First Time(added 07/14)

Dan Loeb, Professor of Oncology at the McArdle Laboratory for Cancer Research, and Adam Zlotnick, Professor of Molecular and Cellular Biochemistry at Indiana University, have come up with a picture of a virus that infects millions of people worldwide and kills many in the Third World. This advance marks a signficant leap forward in understanding how the virus replicates and how to stop it from doing so.

View the Full Article

Horizontal rule
Robert Kalejta Receives Grant from Avon Foundation (added 06/14)

Robert Kalejta, Associate Professor of Molecular Virology and Oncology, and his postdoc, Che Liu, recently received a $200,000 grant from the Avon Foundation to study the role of human cytomegalovirus in breast cancer. Che attended the Avon Walk event in Chicago (see photos below).

CheLiu_Avon1CheLiuAvon2

Horizontal rule
Nate Sherer Selected as Recipient of the Shaw Scholars Award (added 06/14)

Nathan M. Sherer, Assistant Professor of Molecular Virology and Oncology, received a $200,000 grant through the Greater Milwaukee Foundation's competitive Shaw Scientist Program.

View the full article

Horizontal rule

New Tumor-Targeting Agent Images and Treats Variety of Cancers (added 06/14)

William F. Dove, Professor Emeritus of Oncology and Medical Genetics, is highlighted in a recent University of Wisconsin School of Medicine and Public Health News article on a new tumor-targeting agent.

View the full article

Horizontal rule
Pitot Family Among Honorary Race Chairs for the 2014 Komen Race for the Cure (added 05/14)

The 2014 Honorary Race Chairs for this year's Komen Race for the Cure include Dr. Henry C. Pitot and his family. The Pitot family has been involved in the Race for the Cure over the years, but that involvement grew stronger when their daughter was diagnosed with breast cancer in 2001.

Read about the Pitot family and the Komen Race for the Cure here

The Pitot family was interviewed for two different news segments on the local CBS channel; view the videos here: Interview 1 Interview 2

Horizontal rule
THANK YOU - Town of Elba - Dodge County, WI (added 05/14)

The McArdle Laboratory for Cancer Research would like to say THANK YOU to the Town of Elba - Dodge County, WI. The Town of Elba raises money through their Elba Township Charity Drive, and proceeds that come to McArdle are so designated by various members of the community. The Town of Elba - Dodge County has contributed thousands of dollars to McArdle over the years. We would like to thank everyone involved in this charity drive for your support. This contribution provides critical support to our efforts to identify the causes of cancer and to develop more effective approaches for preventing and treating cancer. The research we perform in the McArdle Laboratory would not be possible without the generous support of people like you!

Horizontal rule
Dr. Richard Burgess receives honorary Doctor of Science Degree (added 05/14)

Richard Burgess, James D. Watson Professor Emeritus of Oncology, received an honorary Doctor of Science degree at this year's commencement at the Watson School of Biological Sciences, Cold Spring Harbor Laboratory.

View the full article

PRESS RELEASE (draft prepared by Richard Burgess 4/14/14)
May 4, 2014, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Dr. Richard R. Burgess received an honorary degree (Doctor of Science honoris causa) from the Watson School of Biological Science at its 11th commencement ceremony May 4, 2014 at Cold Spring Harbor Laboratory (CSHL) on Long Island. He was honored for his seminal scientific and teaching accomplishments.
Dr. Burgess is James D. Watson Professor Emeritus of Oncology in the McArdle Laboratory for Cancer Research in the University of Wisconsin-Madison School of Medicine and Public Health and has been at UW-Madison since 1971.
Dr. Burgess was a graduate student of James D. Watson at Harvard (1964-1969) in the Programs for Biochemistry and Molecular Biology. His graduate research project was to determine the subunit structure of RNA polymerase, the central enzyme in the flow of genetic information from DNA to RNA. In the course of this work, he developed several new methods to purify and characterize the RNA polymerase from the bacterium E. coli. He first identified and defined the four subunits β', β, α, and ω of the core enzyme. This enzyme is able to carry out RNA synthesis in vitro. He then discovered that there was yet another subunit, the sigma factor, that bound reversibly to core and directed it to bind to and correctly initiate specific transcription at promoters. He predicted that different sigmas might exist, each with a different promotor specificity, which could exert a broad level of control of cellular gene expression. This prediction proved correct. Sigma was the first positive transcription factor and Dr. Burgess' work set the stage for a tremendous burst of research about the complex machineries of transcription and gene regulation that continues today.
In 1991, Dr. Burgess was invited to be an instructor in a newly organized CSHL course on Protein Purification and Characterization. Each April from 1992-2013, he taught in this outstanding two-week, 14-hour-a-day laboratory/lecture course. He loved teaching in this course and being a part of the long, outstanding tradition of teaching and scientific communication that has been the enduring hallmark of CSHL. He was one of the longest-serving instructors in CSHL teaching history.

Horizontal rule
Meet Our Researchers: Robert Kalejta - An Evolutionary Chess Match (added 05/14)

Rob Kalejta, Associate Professor of Molecular Virology and Oncology, is featured in the current "Meet Our Researchers" on the University of Wisconsin School of Medicine and Public Health website.

View the article/video

Horizontal rule
THANK YOU - 9th Annual "Night of Hope" (added 02/14)

The McArdle Laboratory for Cancer Research would like to say THANK YOU to Verona Area School and community members who teamed up with Gray’s Tied House of Verona to sponsor their 9th Annual “Night of Hope”.  All proceeds from this event were donated to cancer research at the McArdle Laboratory in honor of all Verona Area School District families who have been affected by cancer.  This year over $5,600 was raised; over the last nine years, this fundraiser has contributed over $28,000 to the McArdle Laboratory for Cancer Research.

We would like to thank everyone involved in this event for your continued support.  A special thank you to the Verona Area School staff who organized the event, to Gray’s Tied House for hosting the event, and to everyone who donated money toward this fundraiser.  This contribution provides critical support to our efforts to identify the causes of cancer and to develop more effective approaches for preventing and treating cancer.  The research we perform in the McArdle Laboratory would not be possible without the generous support of you and many others.

Horizontal rule
THANK YOU - Freedom High School Student Council Members (added 02/14)

The McArdle Laboratory for Cancer Research would like to say THANK YOU to the Freedom High School Student Council Members and others who raised close to $2,000 for research at the McArdle Laboratory for Cancer Research.  Each year, the Freedom High School student council hosts a formal dance to acknowledge various clubs throughout the school.  Court members fundraise and seek out donations for about a week before the dance (and the court members who raise the greatest amount reign as King and Queen!).  All proceeds are then sent to the McArdle Laboratory.

Freedom Schools chose McArdle Laboratory as the recipient of this fundraiser because they appreciate that all donations that McArdle receives go directly to cancer research.  We would like to thank everyone involved in this event for your support.  This contribution provides critical support to our efforts to identify the causes of cancer and to develop more effective approaches for preventing and treating cancer.  The research we perform in the McArdle Laboratory would not be possible without the generous support of you and many others.

Horizontal rule
Great Lakes Nuclear Receptor Conference will be held on Oct 17-18 (added 02/14)

Contact organizers, Drs. Elaine Alarid and Wei Xu, for more information.

Horizontal rule
Bill Sugden and colleagues use astronomy to follow cancer-causing virus (added 02/14)

Bill Sugden, PhD, James A. Miller Professor of Oncology and American Cancer Society Research Professor, and colleagues at the McArdle Laboratory are using astronomy to follow a cancer-causing virus.
(Read more about this exciting research here)

Horizontal rule
Shigeki Miyamoto Named Recipient of Kellett Mid-Career Award (added 1/14)

Shigeki Miyamoto, PhD, Professor of Oncology, has been named a recipient of the Kellett Mid-Career Award for 2014. Congratulations to Shigeki on this well deserved honor!

Read about the Kellett Mid-Career Award here

Horizontal rule
9th Annual "Night of Hope" to be held on Friday, January 17, 2014 (added 1/14)

Verona Area Schools have once again teamed up with Gray's Tied House of Verona to sponsor their 9th Annual "Night of Hope" featuring music, raffles, and silent auction, to be held on Friday, January 17, 2014 from 4:00 to 9:00 p.m. at Gray's Tied House, 950 Kimball Lane, Verona, WI. All proceeds from this event will go to cancer research in honor of all Verona area school district families who have been affected by cancer. A portion of all food, gift certificates and beverage sales will be donated to the cause. Over the past 8 years, Verona Area Schools have raised over $23,000 for the McArdle Laboratory for Cancer Research.

Horizontal rule
Horizontal rule

2013

Horizontal rule
McArdle Open House Event held on October 15, 2013 (added 10/13)

McArdle Laboratory held an open house at the "Free House" in Middleton on October 15, 2013 to provide information to the public about our research, our scientists, and to learn more about how to be part of cutting-edge cancer research.
(Read more about the event here)

Horizontal rule
McArdle Students Unveil New Cancer Research Blog (added 9/13)

Read the first blog and learn why the 'McArdle Blog L7' was started.

Horizontal rule

L.I.F.E. Donates Additional Funds to Support Research (added 9/13)

The McArdle Laboratory is proud to acknowledge the continued support of our research directed toward identifying the causes of and effective treatments for myelogenous leukemia by L.I.F.E., Leukemia Ironman Fundraiser for Eric.

L.I.F.E. was founded by the family of Eric McLean of Two Rivers, Wisconsin, who was diagnosed with acute myelogenous leukemia in 2003 and died of this disease on August 23, 2012.

We were visited by Eric’s brother Mike, Mike’s son Mason Eric, and Eric’s parents Mary and Brian McLean on September 19, 2013, during which the McLeans presented a check for $15,000 to support research in the laboratory of Dr. Jing Zhang.  Also pictured is Guangyao Kong, a postdoctoral trainee in Dr. Zhang’s laboratory and Dr. Jim Shull, director of the McArdle Laboratory for Cancer Research.

L.I.F.E. donation photo

Pictured Left to Right: Guangyao Kong, Jing Zhang, Mason Eric McLean, Mike McLean, Mary McLean, Brian McLean, and Jim Shull

Horizontal rule

Jing Zhang receives Scholar Award from Leukemia & Lymphoma Society (added 7/13)

Jing Zhang, Associate Professor of Oncology in the McArdle Laboratory for Cancer Research, has been granted a Scholar Award from the Leukemia & Lymphoma Society (LLS). This award, part of the Career Development Program at LLS, provides a five-year stipend for junior faculty involved in fundamental basic, clinical, and translational research relevant to treatment or diagnosis of leukemia, lymphoma, and myeloma. Dr. Zhang's research will focus on use of a novel mouse model generated in her lab, to test how activation of the MEK/ERK pathway to different degrees differentially affects blood stem cell functions, and whether hyperactivation of this pathway is a leading cause of leukemias. Her results will not only provide insights into basic mechanisms of leukemias but also could potentially lead to a potent and efficacious novel therapy for treating dysregulated Ras signaling-associated leukemias and preventing their further transformation.

Horizontal rule

Richard Burgess receives Entrepreneurial Achievement Award (added 4/13)

Richard Burgess, Professor Emeritus of Oncology, was honored with an Entrepreneurial Achievement Award on April 22. Dr. Burgess was recognized with this award for making a significant impact with his entrepreneurial pursuits.

Read the full article

William Dove Recipient of 2013 Emeritus Faculty Award (added 4/13)

William F. Dove, Professor Emeritus of Oncology and Medical Genetics, was awarded the 2013 Emeritus Faculty Award in Basic Sciences by the Wisconsin Medical Alumni Association. This award is given to a basic scientist who demonstrated long and effective service to the UW School of Medicine and Public Health in teaching and/or research or noteworthy administration, including program development.

Read the full article

Horizontal rule

Elaine Alarid receives Vilas Associates Award (added 4/13)

Elaine Alarid, Associate Professor of Oncology, was named a recipient of the Vilas Associates Award for 2013-2014. This competition recognizes new and ongoing research of the highest quality and significance. The award provides salary support as well as research funding. Professor Alarid's research is focused on elucidating the mechanisms through which estrogens contribute to breast cancer.

Horizontal rule

Wei Xu awarded the 2013 SOT Achievement Award (added 3/13)

Wei Xu, Associate Professor of Oncology, was awarded the 2013 SOT Achievement Award. This award is presented to a member of the Society of Toxicology who has made significant contributions to toxicology. This award consists of a plaque that is presented at the SOT Annual Meeting Awards Ceremony and a cash stipend.

Horizontal rule

Verona Area High School Teachers and Staff Support McArdle Laboratory (added 2/13)

In January 2013, Gray’s Tied House hosted the 8th annual “Night of Hope,” an event organized by Verona Area High School Staff.  This fundraiser to support cancer research began after several high school staff members were diagnosed with or were being treated for cancer. Raffle proceeds and 10 percent of food and beverages sold at Gray’s Tied House went to McArdle Laboratory to support cancer research.  Over the past eight years, thousands of dollars have been raised to support the McArdle Laboratory for Cancer Research through this event.

Thank you to the Verona Area High School Staff, Gray’s Tied House, and all those who attended the event for your continued support.

VeronaHS

Pictured Left to Right: Carly Hasse, Jim Shull (McArdle Director) Diana Trowbridge, Cory Walsh, Mike Hoffmann (McArdle Associate Director), Julie Berndt and Holly Dionne

Horizontal rule

Michael Gould Co-Chairs Major NIH Committee – Report Released (added 2/13)

Dr. Michael Gould, Kelly H. Clifton Professor of Oncology, served as Co-Chairman of the Interagency Breast Cancer and Environmental Research Coordinating Committee (IBCERCC) which recently published a report entitled “Breast Cancer and the Environment - Prioritizing Prevention.”  The report focuses on identifying and mitigating the environmental causes of breast cancer and offers seven recommendations that highlight the need for these coordinated and targeted efforts.

Read the article in the New York Times
Horizontal rule

Meet Our Researchers - Caroline Alexander (added 2/13)

Caroline Alexander, Associate Professor of Oncology, is featured in "Meet Our Researchers" on the University of Wisconsin School of Medicine and Public Health website.

Read the full article

Horizontal rule

Paul Ahlquist Elected to American Association for the Advancement of Science (added 1/13)

Paul Ahlquist, Paul J. Kaesberg Professor of Oncology and Molecular Virology, was recently elected a fellow in the Biological Sciences Section of the American Association for the Advancement of Science (AAAS). He was honored for his significant contributions to the area of molecular virology, viral evolution and pathogenesis.

Selection as an AAAS fellow is a high honor conferred by peers in recognition of distinguished efforts to advance science and its applications. AAAS is the world's largest general scientific society. The tradition of naming AAAS fellows in honor of their achievements dates to 1874.

New fellows will be recognized February 16 at the Fellows Forum, to be held during the AAAS annual meeting in Boston.

Read the full article on the UW-Madison Web site / AAAS Web site

Horizontal rule
Horizontal rule

2012

Horizontal rule

Scientific Conference Honors Waclaw Szybalski (added 04/12)

Scientists from around the world participated in a Symposium "50 Years of Gene Therapy", which was held in Krakow, Poland on September 28-29, 2012 to celebrate the achievements of Dr. Waclaw Szybalski, Professor Emeritus of Oncology.

Horizontal rule

Chris Bradfield receives Kellett Mid-Career Award (added 3/12)

Chris Bradfield, Professor of Oncology, received a Kellett Mid-Career Award. This award, supported by the Wisconsin Alumni Research Foundation (WARF), recognizes outstanding mid-career faculty members. Dr. Bradfield received a flexible research stipend for this award.

Read the full article

Horizontal rule
Horizontal rule

2011

Horizontal rule

L.I.F.E. Donates Funds to Support Research (added 11/11)

The nonprofit organization Leukemia Ironman Fundraiser for Eric (L.I.F.E.) recently donated funds to the McArdle Laboratory for Cancer Research to support research on leukemia. Eric and Michael McLean, who established L.I.F.E. in 2010 with family and friends, presented the donation to Dr. James Shull, Director of the McArdle Laboratory. L.I.F.E. is "dedicated to cancer survivorship by providing assistance to cancer patients in need, scholarship programs, helping someone check off a bucket list, and donating to promising research laboratories."

Read the full article

Horizontal rule

Bill Dove Selected to Give the 2011 Verne Chapman Memorial Lecture

Dr. William F. Dove was selected by The Genetics Society of America to give the 2011 Verne Chapman Memorial Lecture. 

Dr. Dove was recognized by The Genetics Society of American for “his numerous seminal contributions to the field of genetics starting with phage lambda, where he was a member of the faculty for the final 'Phage Course' at Cold Spring Harbor Laboratory, to Physarum polycephalum and most recently mice and rats.  Dr. Dove's laboratory discovered and developed the ApcMin mouse model of colorectal cancer, which has become the most widely used mouse model of cancer, and recently developed the Pirc rat model.  In addition, Dr. Dove has been instrumental in developing efficient procedures for mutagenizing the mouse genome and developing resources for mapping and identifying altered genes, a process that has become an essential tool for mammalian functional genomics.  Dr. Dove was elected to the US National Academy of Sciences in 1998 and the American Academy of Arts and Sciences in 2000.”

Dr. Dove's lecture entitled "Experimental Mammalian Biology: Verne Chapman and the Molecular Genetic Era" was presented at the Mouse Genetics Conference on June 25, 2011.  Dr. Chapman was a leading mammalian geneticist and chairman of the Department of Molecular and Cellular Biology at Roswell Park Cancer Institute in Buffalo when he died in 1995 at the age of 56.

Horizontal rule

Yongna Xing named Shaw Scientist

Horizontal rule

Waclaw Szybalski Receives Prize from Polish President

Professor Emeritus Waclaw Szybalski recently traveled to the Royal Castle in Warsaw, Poland to receive the Order of Polonia Restituta from Poland's President Bronislaw Komorowski. Dr. Szybalski was recognized with the Grand Cross of the Order of Polonia Restituta (i.e., Rebirth of Poland) for his "extraordinary and distinguished service."

The May 3, 2011 award ceremony was part of the celebrations that take place on the National Day of Poland, which commemorates the adoption of the Polish Constitution (on May 3, 1791) - the first written Constitution in Europe and the second in the world following the American Constitution.

According to Wikipedia, "The Order of Polonia Restituta (Polish: Order Odrodzenia Polski; English: Order of Rebirth of Poland) is one of Poland's highest Orders. The Order can be conferred for outstanding achievements in the fields of education, science, sport, culture, art, economics, defense of the country, social work, civil service, or for furthering good relations between countries. It was established on February 4, 1921 and can be awarded to both civilians and soldiers, as well as to foreigners. The Order of Polonia Restituta is commonly believed to be the successor to the Order of the Knights of Saint Stanislaus, Bishop and Martyr (known simply as the Order of Saint Stanislaus) established by the last King of the Polish-Lithuanian Commonwealth - Stanislaw August Poniatowski, to honor supporters of the Polish Crown." Read more here...

Horizontal rule
Bette Sheehan wins the Martha Casey Award

Bette Sheehan was awarded the Martha Casey Award for Dedication to Excellence at the 2011 Academic Staff Excellence Awards Reception on Thursday, April 14, 2011. Read more here.

Horizontal rule
Horizontal rule

2010

Horizontal rule

Gerald C. Mueller 1920-2010

Horizontal rule

Wei Xu receives the DOD Era of Hope Scholar Award

Horizontal rule

Norman Drinkwater receives the Folkert Belzer Award

Dr. Norman Drinkwater, Professor of Oncology, and Dr. John Frey Professor of Family Medicine, have been named recipients of the 2010 Folkert Belzer Award. The Folkert Belzer Award is a “lifetime achievement” recognition for contributions throughout one’s career to the Medical School. Other criteria include the quality and significance of the individual’s academic impact, demonstration of comprehensive excellence, and value to the institution. Finally, the Belzer Award is intended to recognize an individual who may be regarded as an “unsung hero” because of contributions extending over a prolonged period as opposed to a singular academic achievement. The award was presented to Drs. Drinkwater and Frey at the Middleton Society dinner on September 16, 2010.

Horizontal rule

Paul Lambert receives Kellett Mid-Career Award. Read about it here...

Horizontal rule

Jing Zhang receives 2010 ASH Scholar Award. Read about it here...

Horizontal rule
Horizontal rule

2009

Horizontal rule

Janet E. Mertz Named the Elizabeth McCoy Professor of Oncology

Dr. Janet E. Mertz, Professor in the Department of Oncology, recently received a WARF Named Professorship from the University of Wisconsin-Madison Graduate School.  This award is intended to honor UW faculty who have made “major contributions to the advancement of knowledge, primarily through their research endeavors, but also as a result of their teaching and service activities.”  Dr. Mertz’ numerous research accomplishments have included:  discovering mechanisms regulating transcription, RNA processing, and protein synthesis in mammalian cells; determining how gene expression is controlled in several viruses that contribute to some human cancers; and showing that estrogen-related receptor alpha likely plays roles in some hormone-independent breast cancers.  Recently, she documented that females with profound math ability exist, but are frequently inhibited by socio-cultural factors from developing their talents.  Dr. Mertz, a faculty member at the McArdle Laboratory for Cancer Research since 1976, has served on numerous editorial boards and grant review panels and is a Fellow of the American Association for the Advancement of Science.  She has mentored numerous students and postdoctoral trainees and is an active participant in the virology community on the Madison campus.

Dr. Mertz chose to have her Professorship named in honor of Dr. Elizabeth McCoy.  Dr. McCoy received her Ph.D. in bacteriology from the University of Wisconsin in 1929 under the mentorship of Dr. E.B. Fred.  After a year of postdoctoral studies in Europe, Dr. McCoy returned to UW-Madison as a faculty member in 1930, and eventually became the second woman outside of the Schools of Nursing and Home Economics to attain the rank of full Professor.  During her long scientific career until her retirement in 1973, Dr. McCoy studied essentially all areas of microbiology, from very basic to highly applied.  Her areas of research included: staphylococci and botulinum food poisoning; discovery, large-scale production, and the nature of resistance to antibiotics; bacteria involved in commercial fermentations; classification and characterization of viruses that infect bacteria; and the ecological roles of bacteria in fresh water lakes.  She co-taught in the first virology course offered on the Madison campus.  Dr. McCoy co-authored the definitive text on nitrogen fixation and was recognized throughout the world as a truly great microbiologist.  She was also granted numerous patents for her discoveries through the Wisconsin Alumni Research Foundation, including for a method to ferment molasses into the solvent butyl alcohol and for isolation of the antibiotic oligomycin.

Horizontal rule

James Shull named next Chair of Oncology. Read about it here...

Horizontal rule

Jing Zhang wins Shaw Award. Read about it here...

Horizontal rule

Professor Dove receives the 2009 Hilldale Award in the Biological Sciences for excellence in teaching, research and service Read more...

Other McArdle faculty who have received this honor include Drs. Henry Pitot, Waclaw Szybalski, and Howard Temin.

Horizontal rule

Professor Burgess retires after 37 years at McArdle. A Symposium honoring Dr. Burgess was held in August 2009. Click here for pictures

Horizontal rule

Alex Shoemaker Awarded Abbott’s Outstanding Research Team Award

Dr. Alexander R. Shoemaker recently received Abbott’s prestigious Outstanding Research Team Award “for achievements in the pursuit of scientific excellence”.  The Abbott Fund donated $5,000 to the McArdle Laboratory Endowment Fund in honor of Dr. Shoemaker’s Award.  Dr. Shoemaker received his Ph.D. in Genetics under the direction of Dr. William F. Dove at the McArdle Laboratory.  He carried out postdoctoral work at the University of California, San Diego prior to joining Abbott Laboratories in Global Pharmaceutical Research and Development.

Horizontal rule
Horizontal rule

2008

Horizontal rule

Burgess and Szybalski Named AAAS Fellows

McArdle faculty members Richard Burgess and Waclaw Szybalski are among seven UW-Madison faculty members elected to the American Association for the Advancement of Science (AAAS) in 2008. Selection as an AAAS Fellow is a high honor conferred by peers in recognition of distinguished efforts to advance science and its applications. The AAAS is the world's largest general scientific society. The society's mission is "to advance science, engineering, and innovation throughout the world for the benefit of all people."

Richard R. Burgess, UW-Madison professor of oncology, was selected for his contributions to the biochemistry of gene regulation and promoting technology transfer and the commercialization of research as the founding director of the UW-Madison Biotechnology Center.

Waclaw Szybalski, UW-Madison professor emeritus of oncology, was selected for multiple and diverse contributions to the field of molecular genetics and chemical mutagenesis and in particular for his formation of hypoxanthine-aminopterine-thymidine medium, a selection medium for mammalian cell culture.

The new Fellows will be recognized for their contributions to science and technology at the Fellows Forum to be held on February 14, 2009 during the AAAS Annual Meeting in Chicago.

Horizontal rule

Wei Xu receives Shaw Scholar Award
Read more...

Horizontal rule

The year 2008 marked the 100th anniversary of the birth of Dr. Harold Rusch (1908-1988), the founder of the McArdle Laboratory for Cancer Research.

Horizontal rule

Wegner Receives 2008 Robert C. Mierendorf Undergraduate Research Fellowship

Natalie Wegner has been awarded the 2008 Robert C. Mierendorf, Jr. Undergraduate Research Fellowship at the McArdle Laboratory for Cancer Research. This Fellowship was established in 2006 by Dr. Mierendorf’s colleagues at Novagen (now called EMD Biosciences, Inc.), Madison, WI, in appreciation of Dr. Mierendorf’s outstanding leadership throughout his career there. Natalie, a senior majoring in Medical Microbiology and Immunology, will carry out her research in Dr. Paul Lambert’s laboratory. Natalie’s project will focus on DNA Damage Responses and Papillomaviral DNA Replication.

A Milwaukee, WI native, Bob Mierendorf received a B.S. degree in Molecular Biology from UW-Madison in 1974.  Fascinated by all aspects of science, Bob began his research career at the McArdle Laboratory for Cancer Research.  He completed a PhD in Oncology under the direction of Dr. Gerald C. Mueller with his dissertation work on “Glucocorticoid Hormone Action in Friend Erythroleukemia Cells”.  Bob then assumed the position of Director of Research and Development at Promega Corporation.  In 1989, Bob founded, with Warren Kroeker and David Dubbell, a small biotechnology start-up company called Novagen, Inc., and served as Vice President and General Manager.  Novagen was established as a wholly-owned subsidiary of Pel-Freez, Inc., and specialized in the production of custom gene libraries and specialty reagents.  Novagen was the first company to commercialize the pET System (developed by Dr. F. William Studier and his colleagues at Brookhaven National Laboratory), and over the next several years became a leader in protein expression systems.  In January 1998 Novagen was acquired by CN Biosciences (CNBI), and Bob was named President of Novagen.  The following year CNBI was acquired by Merck KGaA, and in 2003 the company officially changed its name to EMD Biosciences, Inc.  Bob served as Chief Technology Officer of CNBI and EMD Biosciences.  Through these many transitions, Bob was instrumental in the growth and the success of the company and the people who work there.

Thanks to Dr. Mierendorf’s colleagues at EMD Biosciences, this Fellowship will be awarded annually to an outstanding undergraduate student who is carrying out research at the McArdle Laboratory for Cancer Research.

Horizontal rule
Horizontal rule

2007

Horizontal rule

Wagner Receives the First Ilse L. Riegel Travel Award

Caroline Wagner, a 4th-year graduate student in Dr. Caroline Alexander’s laboratory, has received the first Ilse L. Riegel Travel Award.  Caroline, who studies breast cancer, will present her work at a Gordon Conference in California in March 2007.  This award is named in honor of Dr. Ilse Riegel and was made possible through donations made in her memory.  Ilse made enormous contributions to the McArdle Laboratory for Cancer Research for over 50 years, first as a postdoctoral fellow in Dr. Gerry Mueller’s laboratory (1952-1954) and then (1954-2004) providing administrative support to the McArdle faculty and caring for thousands of graduate students, postdocs, staff, and visitors.

Horizontal rule

Kenealy Receives First Robert C. Mierendorf Undergraduate Research Fellowship

Brian Kenealy has been awarded the first Robert C. Mierendorf, Jr. Undergraduate Research Fellowship at the McArdle Laboratory for Cancer Research.  This Fellowship was established in 2006 by Dr. Mierendorf’s colleagues at Novagen (now called EMD Biosciences, Inc.), Madison, WI, in appreciation of Dr. Mierendorf’s outstanding leadership throughout his career there.  Brian, a junior majoring in Molecular Biology, will carry out his research in Dr. Elaine Alarid’s laboratory.  Brian’s project will focus on the role of DNA binding in the control of estrogen receptor protein stability in breast cancer.

A Milwaukee, WI native, Bob Mierendorf received a B.S. degree in Molecular Biology from UW-Madison in 1974.  Fascinated by all aspects of science, Bob began his research career at the McArdle Laboratory for Cancer Research.  He completed a PhD in Oncology under the direction of Dr. Gerald C. Mueller with his dissertation work on “Glucocorticoid Hormone Action in Friend Erythroleukemia Cells”.  Bob then assumed the position of Director of Research and Development at Promega Corporation.  In 1989, Bob founded, with Warren Kroeker and David Dubbell, a small biotechnology start-up company called Novagen, Inc., and served as Vice President and General Manager.  Novagen was established as a wholly-owned subsidiary of Pel-Freez, Inc., and specialized in the production of custom gene libraries and specialty reagents.  Novagen was the first company to commercialize the pET System (developed by Dr. F. William Studier and his colleagues at Brookhaven National Laboratory), and over the next several years became a leader in protein expression systems.  In January 1998 Novagen was acquired by CN Biosciences (CNBI), and Bob was named President of Novagen.  The following year CNBI was acquired by Merck KGaA, and in 2003 the company officially changed its name to EMD Biosciences, Inc.  Bob served as Chief Technology Officer of CNBI and EMD Biosciences.  Through these many transitions, Bob was instrumental in the growth and the success of the company and the people who work there.

Thanks to Dr. Mierendorf’s colleagues at EMD Biosciences, this Fellowship will be awarded annually to an outstanding undergraduate student who is carrying out research at the McArdle Laboratory for Cancer Research.

Horizontal rule
Horizontal rule

2002

Horizontal rule

McArdle Welcomes New Students

Nine graduate students joined the McArdle Laboratory for Cancer Research beginning with the Spring 2002 semester. They are: Cellular and Molecular Biology majors Luis Acevedo (Farnham laboratory), Scott Balsitis (Lambert laboratory), Adam Feire (Compton laboratory), Sigrid Holmgren (Lambert laboratory), Larry Kwong (Dove laboratory), Heather Scobie (Young laboratory), and Sara Speros (Alexander laboratory), and Genetics majors Jennifer Dingwall (Burgess laboratory) and Stephanie Nelson (Gould laboratory). They join Oncology students Young-chul Kim (Alexander laboratory), Sang Kyun Lim (Hoffmann laboratory), Scott Lindner (Sugden laboratory), and Linh Nguyen (Bradfield laboratory) to make up the 1st -year McArdle graduate student class. Steve Knight and Bryan Zhao, both in the Hoffmann laboratory, recently transferred to McArdle from other laboratories. Please welcome these new students.

Horizontal rule
Horizontal rule

2001

Horizontal rule

Chen Awarded CRFA Fellowship

Dr. Xiaodi Chen, a postdoctoral research associate in the laboratory of Dr. William F. Dove, has been awarded a fellowship from the Cancer Research Foundation of America (CRFA). The 2-year fellowship will help to support Dr. Chen's research efforts to identify biomarkers for human colorectal cancer and to develop effective methods to detect the early tumors. Dr. Chen's research involves an active collaboration between Dr. Dove's cancer genetics laboratory and the virology laboratory of Dr. John A.T. Young in the McArdle Laboratory for Cancer Research.

Colorectal cancer is the third most common cancer and causes the second most cancer deaths in the United States. This cancer can be completely cured by surgery if it is discovered in its early stages. Therefore, early detection is critical for the reduction of colorectal cancer death. Currently in advanced parts of the world, people with a high risk of colorectal cancer are recommended to have regular tests to detect early colorectal cancers. However, the current tests for early detection are inaccurate, expensive or unacceptable by the general public. With several new approaches using mutant mice that develop intestinal tumors, Dr. Chen aims to find genes that produce tumor-associated products. These genes and their products will be explored as "biomarkers" for the detection of early tumors. Sensitive methods to detect these tumor biomarkers in serum and stool samples will first be explored in mice. The biomarkers that can be sensitively detected in the mouse will be used to investigate the corresponding human biomarkers. This project, if successful, aims to develop prompt and economical methods broadly acceptable by the public, to accurately screen for early colorectal tumors in the high-risk population and, eventually, the general population.

Dr. Chen, who began his work at the McArdle Laboratory last year, received his Ph.D. degree from the University of Missouri-Columbia. The CRFA is a non-profit health foundation, located in Alexandria, VA, whose mission is "the prevention of cancer through scientific research and education".

Horizontal rule

Nobel Laureate Günter Blobel Visits UW-Madison

by Jennifer Michalowski

Dr. Günter Blobel, 1999 Nobel Laureate for Physiology or Medicine, visited the University of Wisconsin-Madison campus recently to speak about his research on protein targeting.

Dr. Blobel, professor at Rockefeller University, was awarded the Nobel Prize for his discovery that "proteins have intrinsic signals that govern their transport and localization in the cell."  In addition to identifying these signals, he has characterized the mechanisms whereby they direct a cell's proteins to the correct compartments and enable their transport across membranes.

Building on his studies on the localization of proteins to the endoplasmic reticulum, Blobel found in 1980 that basic principles governed the trafficking of proteins to other organelles as well.  Newly synthesized proteins are equipped with short sequences of amino acids that act as "address tags".  These signal sequences direct proteins to the correct compartment, where they are recognized by binding proteins that facilitate passage through a channel in the organelle's membrane.

Dr. Blobel earned a Ph.D. in Oncology at the McArdle Laboratory for Cancer Research, where he worked with Professor Van R. Potter on the distribution of ribosomes within cells.  Professor Potter remembers Blobel as an independent student who required little guidance.  He described Dr. Blobel's approach to scientific questions as beginning with "a speculative metaphor in advance of any experimental evidence."  Indeed, Dr. Blobel described the 1971 model in which he first postulated that signal sequences directed proteins to their appropriate destinations as "a wild scheme for which there was absolutely no evidence."

"The genius of the man," Potter commented, "is to say 'how can I test this?'  He is just about without equal on that end."

Despite the tremendous strides Dr. Blobel has made in uncovering the mysteries of protein targeting, he remains humbled by how little we know.  "I think most of the questions are left," he said.  "What is left to be done is humongous."

While visiting the Madison campus, Dr. Blobel also presented a talk on reconstruction efforts in Dresden, Germany, a once-prominent cultural center destroyed during World War II.  Fifty years after witnessing its bombing, Dr. Blobel founded the Friends of Dresden organization to support Dresden's restoration.  He has donated most of his Nobel Prize money to that cause.

Horizontal rule
Horizontal rule

2000

Horizontal rule

Ahlquist and Gould awarded WARF Named Professorships

Drs. Paul Ahlquist and Michael N. Gould have been selected to receive WARF Named Professorships in honor of their significant research contributions, as well as their contributions to teaching and service. Effective July 1, 2000, Dr. Ahlquist will be the Paul J. Kaesberg Professor of Plant Pathology, Molecular Virology, and Oncology, and Dr. Gould will be the Kelly H. Clifton Professor. Both Drs. Kaesberg and Clifton are professor emeritus at the University of Wisconsin-Madison and were leaders in their fields.

Horizontal rule

Bradfield receives the SOT Achievement Award


Dr. Christopher A. Bradfield recently received the 2000 Achievement Award from the Society of Toxicology. The Achievement Award is given to an investigator who is within 15 years of receiving the doctorate degree and who has made ground-breaking research contributions in the area of toxicology.
Horizontal rule

Dove elected to the American Academy of Arts and Sciences

Dr. William F. Dove has been elected as a Fellow of the American Academy of Arts and Sciences. The Academy "honors leading intellectuals from both this country and abroad in every field and profession." Dr. Dove's election to the Academy recognizes his distinguished contributions to his profession. Newly elected members will be formally inducted into the Academy at a ceremony to be held at the House of the Academy in Cambridge, MA, in October 2000.

Horizontal rule

Four receive Hilldale Undergraduate/Faculty Research Awards

Heather Barnes (Lambert laboratory), Angela Speer (Hoffmann laboratory), Jesse Waggoner (Dove laboratory), and Kathleen Worringer (Sugden laboratory) have been selected to receive 2000-2001 Wisconsin/Hilldale Undergraduate/Faculty Research Awards to carry out research projects at the McArdle Laboratory for Cancer Research. The students were judged on the basis of the originality and intellectual significance of their research proposals. The Awards provide a grant to the student and funds to the faculty supervisor to help defray the costs of research.