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Norman R. Drinkwater, Ph.D.

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N. Drinkwater photo Professor of Oncology
Marian A. Messerschmidt Professor in Cancer Research

B.S., 1974, Biochemistry, University of Wisconsin-Madison
Ph.D., 1980, Oncology, University of Wisconsin-Madison
Postdoctoral research: Michigan State University

Office: 6553 Wisconsin Institutes for Medical Research
Telephone:
Office - (608) 262-7992; Lab - (608) 262-8008
Email: drinkwater@oncology.wisc.edu

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Research Interests: Genetics and molecular biology of carcinogenesis

Research Description: Genetic factors can play an important role in determining an individual's risk for developing cancer. We are studying inbred strains of mice that are highly sensitive to tumor induction in specific tissues as a model for understanding the mechanism of action of cancer susceptibility genes. In many cases, these genes also play an important role in regulating the proliferation or differentiation of normal cells. We are currently attempting to determine the molecular identities of several cancer susceptibility genes using a "reverse genetic" approach, based on first mapping the genes and then using this positional information as starting points for molecular cloning.

Selected recent publications

Kennedy, G. D., Nukaya, M., Moran, S. M., Glover, E., Weinberg, S., Balbo, S., Hecht, S. S., Pitot, H. C., Drinkwater, N. R., and Bradfield, C. A.  Liver Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin is Dependent on the Aryl Hydrocarbon Receptor and TNF/IL-1 Receptors.  Toxicol. Sci., 140(1): 135-143, 2014.

Oberley, C. C., Bilger, A., and Drinkwater, N. R.  Genetic Background Determines if Stat5b Suppresses or Enhances Murine Hepatocarcinogenesis.  Mol. Carcinog., in press, 2014 [Epub ahead of print May 17 2014].

Bilger, A., Poli, E., Schneider, A., Baus, R., and Drinkwater, N.  The Hcs7 Mouse Liver Cancer Modifier Maps to a 3.3 Mb Region Carrying the Strong Candidate Ifi202b.  In:  A. Julianov (Ed.), Liver Tumors, pp. 19-36.  Rijeka, Croatia: Intech, 2012.

Drinkwater, N. R., and Gould, M. N.  The Long Path from QTL to Gene. PLoS Genet., 8(9):e1002975, 2012.

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